Florence SiteLink

Florence SiteLink® is a remote site connectivity platform designed for clinical trial sponsors, CROs, and research sites. It provides an always-on digital link between sponsors and their study sites, enabling seamless distribution, monitoring, and exchange of study documents regardless of where sites are located or what technology they use. SiteLink is purpose-built to eliminate the operational bottlenecks that slow clinical trial timelines, supporting over 7.2 million monitoring workflows per month across 20,000 sites in more than 70 countries.

Unlike competing tools that offer limited coverage or require sites to adopt a specific ecosystem, Florence SiteLink is designed to achieve 100% digital coverage — working with sites that use Florence's own eISF, sites using other eISF platforms, and sites with no eISF at all. With 90%+ eISF adoption rates, SiteLink gives sponsors real-time visibility into document status at every site while giving site staff an intuitive, end-to-end workflow experience they actively want to use.

Document Distribution and Site Coverage

• Distribute start-up and study documents to every site, regardless of the site's existing technology setup
• Ensure 100% digital coverage across sites using Florence, other eISF platforms, or no eISF
• Support remote start-up workflows to activate sites faster and across multiple countries simultaneously

In-App Site Document Workflows

• eSignatures for rapid, compliant document execution
• Fillable forms to streamline data capture at the site level
• Automated task management to reduce manual follow-up
• Version control to ensure sites always work from the correct document
• Access controls to manage permissions across site staff
• Global compliance support to meet regulatory requirements across regions

Remote Monitoring and Document Access

• Always-on remote access to site documents, enabling monitoring without on-site visits
• Automated monitoring audit trails to support regulatory compliance and inspection readiness
• Ability to assign tasks directly to site staff from within the platform
• Increased CRA capacity — saving 20–30 hours weekly and boosting CRA efficiency by up to 25x

Intelligent Document Review, Collection, and TMF Filing

• Sync site documents directly with any eTMF system for improved TMF quality, completeness, and timeliness
• Quality control documents before they are filed to the TMF
• Quickly identify and resolve site document issues to maintain trial momentum
• Achieve a 98%+ eTMF pass rate through automated audit trails, version control, user permissions, and secure in-app redaction

Measurable Outcomes and Customer Results

• Cut study start-up times by up to 40% and reduce study close-out by two weeks
• Supported $8 billion in revenue acceleration for Pfizer
• Activated 149 sites across 6 countries in 30 days using remote start-up, monitoring, and document collection
• Enabled a top-3 global CRO to increase CRA monitoring efficiency by 25x and achieve 95% site adoption
• Helped a CRO increase studies hosted in Florence by 400% within 18 months
• Transitioned sites out of paper workflows with a six-week set-up and activation timeline

Site Enablement Best Practices

• Proactive site engagement to drive adoption and satisfaction
• Focused CRA training and support to maximize platform utilization
• Continual improvement of the site experience based on feedback
• Strategic automation of site workflows to reduce administrative burden

Florence SiteLink integrates with the tools sponsors and CROs use every day, including eTMF and eConsent platforms, enabling seamless data flow and reducing errors across the document management lifecycle. The platform is built with global compliance in mind, supporting clinical research operations across diverse regulatory environments worldwide.