TissueGnostics

TissueGnostics is a Vienna-based life sciences company founded in 2003 that develops whole-slide imaging systems and image analysis software for biological and pre-clinical research. The company serves researchers across a range of scientific fields, providing tools to analyze complex tissue samples and gain detailed insights into tissue structure, cellular interactions, and spatial cell landscapes. With over 20 years of experience, TissueGnostics has accumulated more than 3,000 peer-reviewed customer publications and maintains installations on all continents, with a global team and partnerships spanning numerous countries.

The company's core focus areas include microscope automation, whole-slide imaging, quantitative tissue cytometry, multiplex fluorescence microscopy, spatial phenotyping, and image analysis. TissueGnostics develops its products in close cooperation with academic and industrial partners worldwide, and its solutions are used in oncology, immunology, pathology, dermatology, surgery, and biocompatibility research, among other fields.

TissueFAXS Platform

• A modular, scalable whole-slide imaging platform designed for scanning diverse sample types
• Supports high-throughput imaging and precise cell quantification
• Enables multiplex analysis of protein expression and tissue localization
• Used for AI-driven histopathology applications, including precision oncology
• TissueFAXS Spectra is a variant used in spatial multi-omics workflows, including mapping of cell interactions and quantification of tumor-associated cell populations
• Has been in active use at institutions such as Northwestern University's Center for Advanced Microscopy since 2008

StrataQuest

• Image analysis software that processes imaging data into publication-ready results
• Supports analysis of the tumor microenvironment, immune cell phenotyping, and spatial distribution assessment across entire slides
• Offers predefined pipelines as well as advanced analysis options for complex research questions
• Includes integrated dimensionality reduction tools for exploring complex datasets
• Used in published studies covering COVID-19 T-cell subset analysis, colorectal cancer metastasis, rectal cancer tumor microenvironment characterization, and pancreatic ductal adenocarcinoma
• Described by users as flexible and tailored to specific research needs, including immune microenvironment analysis in cancer research

AppCenter

• A library of predefined workflows designed to streamline and accelerate image analysis
• Allows researchers to access ready-made analysis pipelines without building them from scratch

Core Capabilities

• Whole-slide imaging and automation of microscopy workflows
• Quantitative tissue cytometry for cell counting and phenotype assessment
• Spatial phenotyping and visualization of cellular distribution across tissue sections
• Multiplex fluorescence microscopy for simultaneous analysis of multiple markers
• AI-driven image analysis for histopathology applications
• Support for spatial multi-omics research integrating imaging with molecular data
• Pipeline optimization and customization services provided by an in-house expert team

Customers and Research Applications

• Used at the Medical University of Vienna for immune cell complexity research and dermatology studies
• Deployed at Northwestern University's Center for Advanced Microscopy in Chicago
• Used at the University of Western Australia for colorectal cancer and immune microenvironment research
• Applied at the University Hospital Heidelberg for cancer research involving protein expression and tissue localization
• Used at RWTH Aachen University for biocompatibility studies involving multiplex fluorescence microscopy
• Deployed at the Pan African Cancer Research Institute, University of Pretoria, for precision oncology in Africa
• Applied in published studies in journals including Clinical Immunology, Frontiers in Immunology, and Matrix Biology

Partnerships, Reach, and Company Milestones

• Founded in 2003; celebrated its 20th anniversary in 2023
• Reached a milestone of 3,000 published reference papers and installations on all continents by 2024
• Launched TG Australia in 2023 and is establishing a TG LATAM Division as of 2025
• Entered a partnership with Klein Scientific in 2026 to expand presence across Australia and the Asia-Pacific region
• Has participated in seven EU-funded Marie Skłodowska-Curie Innovative Training and Doctoral Networks, including the "eRaDicate" network
• Involved in the COMET/FFG project "VAScage" focused on stroke research, and the ARC CTET project in collaboration with Monash University and Queensland University of Technology
• Hosted PhD students for the Stop Spread Bad Bugs (SSBB) project addressing antimicrobial resistance
• Revenues grew to 225% of pre-pandemic levels by 2023
• The 8th generation of its tissue cytometry software was released in 2024

TissueGnostics positions itself as a solution-driven company whose product development is guided by researcher feedback, with an emphasis on authentic communication and collaboration with global academic and industrial partners. Its systems and software are used across a broad range of biomedical research disciplines, with a documented track record in peer-reviewed scientific literature.