OnCore CTMS

OnCore CTMS, developed by Advarra, is the industry's most widely adopted clinical trial management system, built in collaboration with leading academic medical centers and cancer centers. It provides a unified platform for managing protocols, participants, finances, and compliance across the full research lifecycle. OnCore is purpose-built for academic medical centers, cancer centers, and health systems conducting anywhere from fifty to 500 or more active trials, and is currently trusted by over 80% of top NIH-funded institutions managing more than 100,000 active studies.

Designed to centralize all clinical trial operational data in one place, OnCore offers the flexibility to tailor workflows to the specific needs of each organization. Its collaborative development model — shaped in partnership with leading research institutions and the Onsemble customer community — ensures the platform continuously evolves to address real-world research challenges.

Core Capabilities

• Protocol and study lifecycle management: Oversee the entire study lifecycle from protocol setup and activation through subject screening, registration, and study close-out, enabling better management of protocol timelines.
• Billing compliance: Centralize billing information to ensure consistency, improve budgeting, and simplify routing across teams and systems, supporting compliant billing processes throughout the trial.
• Research operations management: Gain visibility and financial oversight into all areas of clinical research using a standardized system collaboratively created with leading research institutions.
• Biospecimen management: Available as an additional licensed module to support institutions with biospecimen tracking needs.
• Reporting and analytics: Utilize comprehensive dashboards for actionable insights and strategic operational planning, co-developed with Advarra's Onsemble customer community.

Integrations and Connected Research Ecosystem

• EMR integration: Seamlessly integrates with electronic medical record systems such as Epic and Cerner, supporting RPE integration for protocol and subject information and IHE CRPC billing designations to enhance billing compliance and patient safety.
• Enterprise system integrations: Supports over 480 live integrations, including connections to general ledger systems, eIRB systems via the OnCore API, and Advarra's own suite of tools including eReg, eSource, Analytics, and Payments.
• Business intelligence: Advarra Analytics integrates seamlessly with OnCore to surface sophisticated, easy-to-use data visualizations providing actionable insights related to accrual, study activation, effort, and more, helping organizations identify trends and spot problem areas.

Licensing and Subscription Model

• An enterprise OnCore license includes clinical research management, billing compliance, and numerous integrations as standard.
• Additional modules such as biospecimen management are licensed separately.
• Licensing fees are dependent on the modules selected and the volume of protocols managed.
• An annual subscription fee covers license, maintenance, support, and upgrades.

Community and Collaboration

• OnCore customers gain access to the Onsemble Community, a robust network of the nation's leading clinical research professionals sharing best practices and addressing current challenges.
• The community actively shapes the technologies used in clinical research, with dashboards and features co-developed alongside Advarra's customer base.
• Institutions such as the University of Maryland Greenebaum Comprehensive Cancer Center and Yale Center for Clinical Investigation highlight the value of both the platform and the collaborative community it fosters.

OnCore CTMS is deployed as an annual subscription and supports turnkey integrations with a wide range of enterprise systems, making it a comprehensive solution for institutions seeking to improve data quality, boost staff efficiency, ensure billing compliance, and accelerate clinical research operations.