Fabric Hereditary Panels with ACE

Fabric Hereditary Panels with ACE is an AI-driven genomic interpretation solution from Fabric Genomics, designed for hospitals and clinical laboratories seeking to accelerate and scale their genetic testing workflows. The platform combines curated gene panels with the Artificial Intelligence Classification Engine (ACE) to deliver rapid, highly accurate ACMG variant classification across whole genomes, exomes, and targeted gene panels — covering inherited cancers, ACMG incidental findings, and newborn screening applications.

ACE is currently available for over 4,000 genes spanning the most commonly used genetic testing panels. It is embedded directly into the Fabric Enterprise platform, enabling a complete FASTQ-to-clinical report workflow that reduces turnaround time from sequence to report down to minutes per case.

Core Capabilities

• AI-Powered ACMG Classification: ACE is an extensively validated, automated ACMG classification engine that leverages deep gene and variant annotation to deliver highly accurate variant classification in compliance with ACMG guidelines.
• Broad Gene Coverage: Supports over 4,000 genes across the most commonly used genetic testing panels, including inherited cancer panels, ACMG incidental findings, and newborn screening tests.
• Validated Accuracy: ACE has been validated across more than 50,000 variants to date. In a ClinVar-based validation study using over 4,000 two- and three-star variants, ACE fully classified 95% of pathogenic/likely pathogenic (P/LP) variants and 77% of benign/likely benign (B/LB) variants, achieving 100% concordance with ClinVar classifications and zero incorrect classifications.
• Rapid Turnaround: Reduces the time from sequencing to clinical report to minutes per case, significantly accelerating laboratory throughput.
• Scalability: Removes interpretation bottlenecks, enabling labs to increase case volume while reducing reliance on manual personnel-intensive processes.

Fabric Enterprise Platform Integration

• ACE is embedded within Fabric Enterprise, providing a seamless end-to-end bioinformatics pipeline from raw sequencing data (FASTQ) through to clinical reporting.
• Fabric Enterprise features accurate alignment and variant calling, up-to-date variant annotation, and configurable SOP-based workflows tailored to laboratory processes.
• Deep gene-disease curation within the platform optimizes variant classification for the most common genetic panels across a wide range of clinical indications.
• The software actively reduces variant of uncertain significance (VUS) backlogs and grows a lab's classified variant database with each approved clinical report.

Key Use Cases

• Inherited cancer genetic testing panels
• ACMG incidental findings analysis
• Newborn screening programs
• Panel testing across varied genetic testing indications, from panel curation through variant classification and reporting

Fabric Hereditary Panels with ACE is purpose-built for clinical genomics laboratories and hospital settings that require a scalable, accurate, and fast solution for genetic interpretation. The platform's validated AI classification engine and comprehensive panel coverage make it well-suited for labs looking to modernize their genomic workflows and improve both speed and consistency of clinical reporting.