Fabric Enterprise

Fabric Enterprise is a comprehensive, turnkey genomics platform designed to transform raw genomic data into clinically actionable insights. Built for clinical laboratories, genomics programs, and healthcare institutions, it supports the full spectrum of next-generation sequencing (NGS) analysis, interpretation, and clinical reporting — all powered by Fabric AI. The platform is scalable and purpose-built to deliver fast, accurate results across a wide range of clinical NGS tests, from whole genomes and exomes to hereditary risk and oncology panels.

Fabric Enterprise encompasses two core product lines: Fabric GEM for Rare Disease and Fabric ACE for Hereditary Risk, enabling laboratories to address diverse clinical use cases within a single unified platform.

Supported Clinical Use Cases

• Rare and undiagnosed diseases via whole genome and exome sequencing
• Ultra-rapid NICU and PICU case analysis
• Re-analysis of previously negative cases
• Hereditary cancer risk panels including BRCA1 & BRCA2, HBOC, Lynch syndrome, colon cancer, and inherited cancer syndromes
• Cardiovascular panels covering familial hypercholesterolemia, Long QT, Marfan syndrome, aneurysm and aortopathies, cardiomyopathy, and arrhythmia
• Neurological panels including non-syndromic epilepsies and neuropathies
• Reproductive health testing including newborn screening and carrier screening
• Population health programs aligned with CDC Tier 1 conditions and ACMG secondary findings

Core Algorithms and Analytical Capabilities

• GEM (Gene Expression Model): Next-generation disease gene ranking for rare disease diagnosis, applying mathematics and AI to identify disease-causing gene mutations from whole genome and exome data
• ACE (Automated Variant Classification Engine): Automated variant classification for hereditary risk screening and pediatric panel testing
• VVP (Variant Impact Score): Variant impact scoring used across both panel testing and WGS/WES workflows
• VAAST: Probabilistic gene burden ranking to support rare disease analysis
• Phevor: Phenotype-driven variant prioritization to refine diagnostic accuracy

Key Platform Features

• Near-instant identification of disease-causing genes in rare genetic disease diagnosis
• Accurate alignment and variant calling
• Up-to-date, validated variant annotation
• Probabilistic variant ranking powered by advanced algorithms
• Transparent logic and clearly cited data sources
• ACMG and AMP guideline-driven variant classification and interpretation
• Configurable SOP-based workflows to match laboratory processes
• Customizable clinical report generation
• Full LIMS and EMR integration capabilities

Fabric Enterprise is deployed by leading genomics programs worldwide and is built to meet rigorous regulatory and security standards, including CLIA compliance, HIPAA compliance, and ISO-27001 certification, making it a trusted choice for clinical-grade genomic analysis at scale.