Fabric Genomics

Fabric Genomics is an AI-driven genomics software company that turns genomic data into actionable clinical insight. Powered by advanced AI algorithms, Fabric's software and clinical services help partners accelerate diagnostics across a broad range of clinical applications, including whole genome sequencing (WGS), exome analysis, and gene panel interpretation. Fabric Genomics has been acquired by GeneDx, marking a new chapter in decentralized, AI-powered genomic testing at global scale.

Fabric Genomics serves leading genomics programs worldwide, partnering with institutions such as Rady Children's Institute for Genomic Medicine, Intermountain Primary Children's Hospital, Oxford Nanopore Technologies, and PlumCare, among others. The platform is designed to address the growing bottleneck of genetic disease test interpretation and report generation as test volumes rapidly increase.

Core Platform Capabilities

• Explainable AI-Powered Analysis: Fabric leverages explainable AI to automate genomic interpretation workflows and deliver accurate, prioritized results quickly across whole genomes, exomes, and gene panels.
• Variant Prioritization and Classification: The platform generates a prioritized list of variants and provides automated ACMG classification, significantly reducing manual review time for clinical teams.
• Automated Report Generation: Fabric automates the creation of clinical reports, streamlining the path from raw genomic data to clinically actionable findings.
• High Accuracy: In a study conducted with Rady Children's Hospital, Fabric achieved 98% call accuracy in prioritized top-10 variant results.
• Cloud-Based Scalability: The software is cloud-based and can scale seamlessly from a single test to hundreds of thousands of tests, supporting both small programs and large-scale genomic initiatives.

Clinical Applications and Partnerships

• NICU/PICU Genomics: Fabric Genomics and Oxford Nanopore Technologies have launched an integrated long-read WGS pediatric care solution specifically designed for neonatal and pediatric intensive care unit applications.
• Congenital Heart Defects (CHD): Intermountain Primary Children's Hospital is using WGS powered by Fabric Genomics to revolutionize care for patients with congenital heart defects.
• Newborn Genome Screening: Fabric has entered a strategic partnership with PlumCare to integrate AI with the FirstSteps™ Newborn Genome Screening Program in Greece, expanding access to early genomic insights for newborns.

Deployment and Notable Details

• Cloud Deployment: Fabric's platform is delivered as cloud-based software, enabling flexible and scalable deployment for clinical laboratories and genomics programs of all sizes.
• Global Reach: Fabric Genomics is the solution of choice for leading genomics programs around the world, with partnerships spanning hospital systems, diagnostic laboratories, and screening programs internationally.
• Industry Recognition: Dr. Stephen Kingsmore, President and CEO of Rady Children's Institute for Genomic Medicine, has cited Fabric Genomics as a key partner, highlighting the platform's accuracy, usability, and speed as critical factors in genetic interpretation.
• GeneDx Acquisition: The acquisition by GeneDx positions Fabric Genomics to further expand access to AI-powered genomic testing and advance innovation at a global scale.

Fabric Genomics provides a comprehensive, scalable solution for clinical genomics teams seeking to automate and accelerate the interpretation of complex genomic data, from rare disease diagnosis in critically ill newborns to large-scale population screening programs.