ROSALIND

ROSALIND® is a cloud-based discovery platform and data hub purpose-built for researchers, biologists, and life scientists who want to perform advanced bioinformatics analysis without writing a single line of code. By transforming raw next-generation sequencing (NGS) data into rich, interactive visualizations and actionable insights, ROSALIND enables same-day results and restores the thrill of discovery. Thousands of scientists across more than 60 countries trust the platform with their valuable research across pharma, biotech, academic, and clinical settings.

At its core, ROSALIND positions itself as the Intelligence Platform for scientists — democratizing access to bioinformatics so that insight is never gated behind consulting hours, coding skills, or lengthy pipelines. The platform connects every stage of NGS data analysis end-to-end, from experiment design and quality control through pathway exploration and meta-analysis, all within a single unified environment.

Supported Assay Types and Analysis Modules

• Bulk RNA-seq Gene Expression: DIY bioinformatics for this genomics staple, enabling researchers to go from raw data to differential expression results without programming expertise.
• NanoString GeoMx Spatial Transcriptomics: The recommended and preferred solution for best-in-class GeoMx data analysis, purpose-built to handle the complexity of spatial transcriptomics workflows.
• NanoString nCounter Gene and miRNA Expression: Bruker's recommended and preferred solution for best-in-class nCounter data analysis, allowing users to analyze nCounter data in minutes.
• Single Cell Gene Expression: A complete workflow from FASTQ files to cell clusters and beyond, leveraging Cell Ranger graph-based clustering for deep single-cell exploration.
• Small RNA-seq (Gene Regulation & Anti-Sense): Small RNA-seq data analysis designed specifically for the biologist, covering gene regulation and antisense applications.
• ChIP-seq (Histone Mark & Transcription Factor): Comprehensive ChIP-seq data analysis for histone mark profiling and transcription factor binding studies.
• ATAC-seq (Chromatin Accessibility): Genome-wide chromatin accessibility analysis to support epigenetics research.
• COVID-19 Diagnostic Monitoring System: A dedicated module for SARS-CoV-2 viral mutation tracking and diagnostic monitoring.

Core Platform Capabilities

• No-code bioinformatics: Scientists of every skill level can run advanced analyses independently, eliminating dependence on dedicated bioinformaticians or IT teams.
• Cloud scale and super speed: ROSALIND automatically manages tens of thousands of compute cores and petabytes of storage, dynamically scaling up and down for every experiment to deliver fast results.
• Rich visual experience: Engaging, interactive visualizations replace static CSV files, allowing researchers to jumpstart discovery immediately after an experiment completes.
• 50+ knowledge bases: More than 50 integrated knowledge bases are available within a single platform, supporting pathway exploration, gene ontology, and disease-focused research.
• Gene signatures and Gene List Manager: Researchers can discover, share, and validate gene signatures across experiments and public datasets, evaluating patterns across genes, pathways, and species to accelerate discovery.
• Meta-Analysis with machine learning: Advanced machine learning capabilities enable scientists to find patterns across multiple comparisons and datasets through Meta-Analysis workflows.
• Knowledge Graph and Search: Data is organized for semantic queries, enabling intelligent, connected exploration of biological information.
• Automated contamination detection: The platform intelligently identifies data quality concerns before researchers invest significant time diagnosing unexpected results.
• Sharing and collaboration: Experiments and insights can be shared instantly with project teams and collaborators anywhere in the world, with a full audit trail tracking every change — no offline file transfers or static screenshots required.

Research Areas and Public Datasets

• Immuno-Oncology: Supporting discovery in IO research through dedicated datasets and analysis workflows.
• Breast Cancer: Identifying differentially expressed miRNAs in breast cancer research.
• HIV: Transcriptional and genomic profiling studies of HIV-positive diffuse large B-cell lymphoma (DLBCL).
• Diabetes: Tools and datasets to discover and accelerate Type 1 Diabetes (T1D) research.
• Multi-Omics and Epigenetics: Exploration of multi-omics datasets in epigenetics research.
• COVID-19 Research Community: A global research community analyzing COVID-19 genomic datasets.
• NanoString Mouse Glial Profiling Panel: Exploration of neuroinflammatory astrocyte subtypes in the mouse brain.

Deployment, Licensing, and Customer Segments

• ROSALIND is delivered as a fully cloud-based platform, accessible anywhere and at any time, with no local infrastructure required.
• Subscription tiers are available for pharma, biotech, and academic researchers, including Enterprise, Professional, and Academic plans.
• Specialized licenses are offered for service providers, contract research organizations (CROs), and academic core labs, enabling these organizations to deliver ROSALIND-powered analysis to their own clients.
• A 14-day free trial is available, along with demo options for prospective users.
• The platform is trusted by leading institutions globally, with thousands of scientists across 60+ countries actively using ROSALIND.

Education and Support Resources

• ROSALIND Academy and the ROSALIND Knowledge Hub provide structured learning resources for users at all levels.
• Dedicated masterclasses are available for NanoString nCounter Gene Expression and NanoString GeoMx Spatial Transcriptomics, helping researchers get the most from these specific workflows.
• A network of service providers, CROs, and academic core facilities that use ROSALIND is available for researchers who prefer to work with an expert partner.

ROSALIND was founded by Tim Wesselman, formerly a Vice President at Hewlett-Packard, with the vision of bringing advanced computing technology into the life sciences to empower researchers, clinicians, and drug developers to accelerate genomic discoveries. The leadership team brings decades of combined experience in bioinformatics, high technology, and software development — including Chief Science Officer Jean Lozach, who contributes more than 25 years of expertise in genomics, bioinformatics, and information technology from Illumina and UCSD.