Lumos

Lumos is a sophisticated multiwell light delivery system designed to facilitate the integration of advanced optical assay methodologies such as optogenetics into in vitro research. The device provides independent control of light delivery in each microplate well, enabling market-leading light intensities across four selectable wavelengths: blue, green, orange, and red. This flexibility allows for fully customizable stimulation patterns that can be adjusted with microsecond precision.

The system pairs seamlessly with Axion's Maestro Pro and Maestro Edge platforms, combining optical stimulation with simultaneous electrical monitoring of cell network activities. It features a range of configurations, supporting 24-, 48-, and 96-well plates to accommodate various experimental needs.

Key Features

• High throughput: Concurrent light delivery across 24, 48, or 96 microplate wells.
• Configurable: Control up to 192 LEDs independently with dynamic precision.
• Wavelength Coverage: Spans four colors to selectively stimulate common opsins.
• Environmental Control: Compatible with temperature and CO₂ regulation for extended experiments.
• User-Friendly: Intuitive software with drag-and-drop design of light patterns.

With topside light delivery, Lumos ensures uniform distribution across each well, keeping the plate bottom free for additional analytical interfaces, like imaging or electrophysiology.

Applications

Lumos is applicable in controlling cell biology and cell activity.

• Cell Biology Control: Applicable in signal pathway manipulation, gene editing, and inducing cell growth.
• Cell Activity Control: Utilize optogenetics to manage membrane potentials and cell activity by engaging light-sensitive ion channels.

Lumos is an award-winning innovation in high-throughput, optogenetic-enabled platforms, providing researchers unprecedented control and assay customization capabilities. It supports a flexible range of experiments, from cardiovascular and neural studies to detailed observation of cell activity and response.