CytoView MEA Plate

The CytoView MEA plate is a sophisticated multiwell microelectrode array plate designed to provide unmatched access to cellular electrical networks. It features a thin, transparent well bottom that facilitates culture visualization and allows for assay multiplexing, offering flexibility in experimental setups.

Available in various formats including 6-, 12-, 24-, 48-, and 96-well plates, these plates boast an industry-leading electrode count per well, up to 64 electrodes. This high electrode density ensures the capture of low-noise signals, making it suitable for extended use across days, weeks, or even months.

Key Features

• Record high-quality data: Equipped with PEDOT electrode technology, the plates offer excellent signal quality, essential for detailed cardiac and neural assays.
• Visualize your cells: The transparent plates are compatible with light microscopy, allowing for daily monitoring of cell cultures.
• Assay multiplexing: Capable of being used with top- or bottom-read fluorescent and luminescent plate readers, these plates offer flexibility with black or white walls depending on the application needs.

In addition to robust data collection, the transparent well bottoms enable brightfield imaging, facilitating the confirmation of cell spotting accuracy and assessment of cell culture health and network connectivity. This feature supports multiplexing of fluorescence- or luminescence-based assays to provide complementary endpoints.

Both cardiomyocytes and neurons can be effectively studied on the CytoView MEA plates, which demonstrate excellent cell coverage and high signal-to-noise ratios, as expected by users.

By employing reporter-based assays alongside electrophysiological data, researchers can gain supplemental insights, such as understanding compound mechanisms of action. For example, within neurotoxicity assays, combining MEA data with fluorescence lactate dehydrogenase (LDH) assays facilitates more accurate compound classification.

Applications

The CytoView MEA plate is suitable for diverse applications, including exploring neural network activity related to autism, characterizing cardiomyocyte function for cardiovascular disease research, and monitoring cardiac differentiation and maturation. It can also evaluate the proarrhythmic risk in CiPA-style studies, enhance physiological relevance through optical or electrical stimulation, and measure activity in complex cell models like iPSC-derived neuromuscular junctions. These capabilities make it a versatile solution for life science research and drug development.