QP-Brain

QP-Brain® is an AI-based software tool developed by Quibim for the quantitative analysis of brain MRI, targeting early detection and monitoring of neurological diseases. It is designed for clinical radiology settings where there is a need to objectively measure brain atrophy and white matter hyperintensities (WMH), particularly in the context of aging populations and neurodegenerative conditions such as Alzheimer's disease.

The software automates the extraction of quantitative data from brain MRI exams, consolidating measurements of brain structure volumes and WMH load and location. It supports radiological reporting by delivering objective, quantitative results that complement visual findings, and integrates directly into existing hospital workflows via PACS.

Core Analytical Capabilities

• Segments and measures absolute and relative volumes of grey matter, white matter, and cerebrospinal fluid across 132 distinct brain regions (left and right).
• Detects and segments white matter hyperintensities using a patented AI ensemble approach that filters out physiological hyperintensities such as ependymal enhancements.
• Accepts 2D FLAIR input for WMH segmentation, removing the requirement for 3D-T1 acquisition.
• Compares patient data against an extensive normative database to identify early changes in brain atrophy and lesion load.
• Supports longitudinal, objective tracking of disease progression over time.

Reporting and Workflow

• Generates structured, quantitative radiology reports that are sent directly to PACS, supporting report standardization.
• Outputs appear as an additional series within the patient folder in standard hospital PACS environments, requiring no additional workstations or viewing software.
• Automatically receives brain images from PACS via query/retrieve functionality, integrating into existing clinical workflows without manual image transfer steps.
• Provides quantitative display of imaging findings including volumes of key intracranial structures and WMH load and location.

Regulatory Status and Compliance

• QP-Brain® holds CE marking, UKCA marking, and FDA 510(k) clearance, among other regulatory approvals.
• Compliant with GDPR and HIPAA privacy regulations.
• Installed on a hospital server behind the firewall, with anonymized rendering typically performed through a secure cloud environment such as AWS or Microsoft Azure.

QP-Brain® is intended to improve diagnostic accuracy and reduce human error in radiological assessment by providing objective, reproducible quantitative data. Its compatibility with standard hospital infrastructure and compliance with international privacy and regulatory standards makes it applicable across a range of clinical settings.