Mnova MSChrom

Mnova MSChrom, developed by Mestrelab, is a unified software solution designed to process, analyze, and report LC- and GC-MS data from multiple instrument vendors and file formats. It is suited for both academic and industrial environments, enabling chemists, analytical scientists, and researchers to work with diverse experimental setups through a single, intuitive interface — eliminating the need to learn and maintain multiple vendor-specific software packages.

By automating key analytical functions such as data import and visualization, integration, background subtraction, extracted mass chromatogram display, molecule matching, and molecular formula enumeration, Mnova MSChrom helps users work more efficiently and reproducibly. It also supports seamless combination of LC/GC-MS data with NMR and other spectroscopic data within one platform for comprehensive, multi-technique analyses.

Core Processing and Analysis Features

• Integrated environment to visualize and analyze LC- and GC-MS data within a single document
• Baseline Correction for improved data quality
• Peak Picking to identify and characterize chromatographic peaks
• Blind Regions to exclude unwanted areas from analysis
• Background Subtraction to isolate signals of interest
• Extracted mass chromatogram display for targeted compound analysis
• Molecule matching and molecular formula enumeration for compound identification
• Streamlined reporting tools for efficient documentation of results

Key Benefits

• Centralized LC- and GC-MS Analysis: All LC- and GC-MS experiment data can be analyzed in one platform, simplifying workflows and improving reliability
• Adaptable to Any Workflow: Adjusts to academic or industrial environments, supporting evolving research needs and diverse experimental setups
• Easy to Learn and Use: Intuitive design allows users to focus on interpreting results rather than mastering complex software
• Time-Saving Automation: Automating data processing, analysis, and reporting frees scientists to prioritize high-value scientific tasks over routine work
• Powerful Automated Modules: Advanced tools support reaction optimization, compound purification, quantification, instrument testing, and more, streamlining both routine and complex analyses

High-Throughput and Advanced Workflows

• Supports high-throughput experimentation (HTE) workflows through automated data processing and centralized management
• Enables standardized outputs suitable for AI/ML integration, as highlighted in webinars featuring collaborations with organizations such as AstraZeneca
• Chrom Reaction Optimization (Chrom RO) module available for reaction scale-up and optimization of dozens of reaction variables
• Expert tools for peak picking, spectral display, and spectral subtraction in hyphenated MS experiments

Related Modules and Solutions

• Mnova Gears: Automation for analytical data workflows
• Chrom Reaction Optimization: Automated solution for chemical reaction optimization
• Affinity Screen: Automated solution for AS-MS screening and hit identification
• Chrom SST: Automated data analysis for system suitability testing
• Chrom Best Method: Automated evaluation and selection of optimal chromatographic methods
• Chrom QC: Automated purity and concentration assessment from LC-MS data

Mnova MSChrom supports a wide range of file formats from multiple instrument vendors, with full documentation available through the Mnova Manual and a dedicated list of supported LC/GC-MS file formats. The platform is applicable across solutions including structure characterization, reaction monitoring and optimization, ligand screening and binding, compound identification and quantification, instrument performance testing, compound purification, and data workflow automation.