Mindpeak Esophagus PD-L1

Mindpeak Esophagus PD-L1 is a stand-alone software module developed by Mindpeak GmbH for automated analysis of digital histopathology images from PD-L1-stained esophageal squamous cell carcinoma tissue samples. It is intended for Research Use Only and is not for use in diagnostic procedures. The tool is designed to assist cancer researchers and pathologists by automating the detection and quantification of PD-L1 expression in esophageal cancer cells, reducing the burden of manual cell counting and scoring tasks.

The software operates as a "0-Click" solution: using background image pre-calculation, all detected and classified cells are instantly visualised upon loading a digital slide, requiring no manual initiation of the analysis. Mindpeak Esophagus PD-L1 was developed with lab-specific variations in mind — including differences in slide preparation, staining, and imaging — to provide consistent results across different laboratory environments.

Key Capabilities

• Detects and classifies immunohistochemically (IHC) stained tumor cells within whole slide images as either positively stained (tumor positive) or not stained (tumor negative).
• Calculates a Tumor Proportion Score (TPS), defined as the number of positive tumor cells divided by the total number of tumor cells (positive plus negative).
• Differentiates between tumorous and non-tumorous structures, supporting more accurate scoring within the tumor microenvironment.
• Supports a broad range of slide scanners, allowing integration into existing laboratory workflows.
• Provides explainable AI (xAI) outputs to support pathologist trust in automated results.

Analysis Workflow

1. Retrieve or select a whole slide image with IHC PD-L1 staining suited for automated analysis.
2. The software performs whole slide analysis and displays the results automatically.
3. Review, adjust, and correct the automated results using an integrated interactive viewer module.
4. Make a final analytic decision based on the reviewed output.

Software and Hardware Requirements

• Mindpeak Esophagus PD-L1 functions as a stand-alone software module and must be integrated into an interactive image viewer that allows users to manually select or correct regions of interest.
• The software runs as a web service, available either as a cloud deployment or as an on-premise server installation within the laboratory network.
• The cloud variant is specified and provided by Mindpeak or its distribution partners and requires no additional hardware from the user.
• For on-premise deployment, minimum hardware requirements are available upon request from Mindpeak.

Mindpeak GmbH, founded in 2018 and headquartered in Hamburg, Germany, with a presence in Cambridge, MA, builds AI and deep learning-based automation tools for visual diagnosis in pathology. All products, unless otherwise stated, are intended for Research Use Only and not for use in diagnostic procedures.