IBDExplore

IBDExplore™ is an AI-powered histopathology panel developed to advance the next generation of inflammatory bowel disease (IBD) therapies. By analyzing H&E-stained whole slide images (WSI), IBDExplore spatially characterizes the inflammatory microenvironment, delivering comprehensive, quantitative insights that support clinical development and research workflows. It is intended for research use only and is not for use in diagnostic procedures.

Currently built and fully assessed on Ulcerative Colitis biopsies, IBDExplore is designed for pharmaceutical and biotech teams seeking scalable, data-rich pathology solutions to fuel clinical development insights across patients, timepoints, and scientific hypotheses. The platform has also been qualitatively assessed in Crohn's Disease, with options available to extend its application to resection samples.

Core Capabilities

• Identify: Automated, rapid, and scalable classification across 12 distinct tissue regions and 10 cell types within the inflammatory microenvironment.
• Quantify: Generation of more than 1,000 human interpretable features (HIFs) that spatially quantify cells and tissue regions across whole slide images.
• Apply: Comprehensive data output directly enables analysis across patients, timepoints, and diverse research hypotheses to fuel clinical development insights.

Product Specifications

• Indication: Ulcerative Colitis (with qualitative assessment in Crohn's Disease also available)
• Intended Use: Research use only — not for use in diagnostic procedures
• Stain Type: Hematoxylin and Eosin (H&E)
• Compatible Scanners: Leica Aperio® AT2 and GT450
• Outputs: A panel (.xlsx) of more than 1,000 quantitative human interpretable features; model prediction overlays of cell types, tissue regions, and crypt classification
• Sample Type: Primarily built for mucosal biopsies, with options to leverage the platform on resection samples

Supporting Resources and Publications

• Webinar: The Role and Opportunity of AI-Powered Digital Pathology in Ulcerative Colitis Research and Clinical Development (November 2022)
• Publication: Artificial Intelligence Applications in Inflammatory Bowel Disease: Quantifying the Mucosal Microenvironment of Ulcerative Colitis (October 2022)
• Publication: Quantitative and Explainable AI-Powered Approaches to Predict Ulcerative Colitis Disease Activity from H&E-Stained Whole Slide Images (January 2023)
• Article: Artificial Intelligence Enables Quantitative Assessment of Ulcerative Colitis Histology (February 2023)

IBDExplore is compatible with Leica Aperio® AT2 and GT450 scanners and is optimized for mucosal biopsy samples. Teams interested in applying IBDExplore to resection samples or gaining deeper histological insights into Crohn's Disease are encouraged to contact the business development team directly.