Green Button

Green Button® is a clinical informatics consult service from Atropos Health that generates real-world evidence (RWE) in response to clinical and research questions. It is designed for clinicians, researchers, and business stakeholders who need on-demand, publication-grade observational research without managing the underlying analytics themselves. Users submit a question and receive a novel retrospective observational study, clinician quality-controlled, within 48 hours.

The service has been used to convert over 10,000 clinical questions into studies run on behalf of clients, with a reported 100% success rate in publishing resulting studies in peer-reviewed journals, including outlets such as Cell and NEJM Catalyst, with over 50 publications to date. Clients have attributed $100 million in savings across expedited analytics, maximized real-world data (RWD) assets, medication cost savings, patient throughput, and care management programs.

Core Capabilities

• Delivers publication-grade retrospective observational study reports in under 48 hours from question submission
• Every study is reviewed and quality-controlled by Atropos Health clinicians
• Supports a Q&A-style evidence generation workflow suited to clinical and business stakeholders
• Provides 24×7 access to the service
• Includes 1:1 meetings with Atropos Health clinicians as part of the consult process
• Runs on a client's own real-world data or on the Atropos Evidence™ Network

Output Formats

• Prognostograms
• Cohort counts in real-world data
• Clinical phenotypes
• Data visualizations
• Full observational research reports suitable for peer-reviewed publication

Typical Use Cases

• Assessing outcomes and subsequent therapies for melanoma patients who received adjuvant PD1 inhibitors
• Identifying incidences of risk factors, procedures, and complications in cholesteatoma patients
• Determining how many surgical patients at a given hospital had a preoperative ICD-10 code related to depression
• Comparing clinical endpoints across classes of FDA-approved pharmacotherapy for Parkinson's disease
• Characterizing unmet need in disease areas such as multiple myeloma
• Evaluating whether multiple sclerosis patients admitted to hospital have longer lengths of stay when receiving typical versus atypical antipsychotic medications

Workflow

1. Submit a clinical or research question through the Green Button® service
2. Atropos Health runs the study on the relevant real-world dataset
3. A clinician reviews and quality-controls the study output
4. The client receives a publication-grade observational research report within 48 hours
5. Studies can be re-run on the client's own data to support policy changes or precision medicine initiatives

Green Button® is one of several automation solutions offered by Atropos Health, alongside ChatRWD®, Forge®, and the Atropos Evidence™ Agent. It integrates with the broader Atropos platform, including the GENEVA OS® data infrastructure and the Atropos Evidence™ Network, and is applicable across health system and life sciences use cases including HEOR, medical affairs, research and development, and value-based care.