GOSTAR Large Molecules

GOSTAR™ Large Molecules, developed by Excelra, is a fully custom-curated database designed to support biologic drug discovery and development across three major large molecule modalities: peptides, oligonucleotides, and antibodies. It is intended for researchers and organizations working in structural biology, therapeutic development, and AI-driven drug discovery who require high-quality, targeted data to guide molecule design, assess the competitive landscape, and identify patentable space.

The database is built on a fully manual curation model, meaning each data set is assembled to match the specific research needs of the requesting organization. All curated data undergoes a three-stage quality control process certified under QMS-ISO-9001:2015, with a curation throughput of up to 24 molecules per day and a minimum turnaround time of 48 hours. Data is delivered in XLS, CSV, or TSV formats, and ongoing updates can be arranged at a frequency agreed upon with the client.

Antibody Data Coverage

• Supports monoclonal antibodies (mAb), bispecific antibodies (BsAb), and antibody fragments (Fab)
• Provides data on amino acid sequences and target information
• Includes pharmacokinetic data
• Covers physical properties such as thermostability and isoelectric points

Oligonucleotide Data Coverage

• Covers antisense oligonucleotides (ASOs) and RNAi modalities including siRNA and miRNA
• Includes more specialized molecule types such as DNAzymes and CpG oligodeoxynucleotides (CpG ODN)
• Provides information on which modalities are being used against specific targets
• Supports identification of effective sequences and available IP space

Peptide Data Coverage

• Covers a wide range of peptide therapeutic targets including fusion proteins, hormones, growth factors, cytokines, and interferons
• Data sets are assembled based on the specific activity and target specified by the client
• Supports competitive landscape analysis and identification of opportunities for new molecule development

Curation and Quality Control Process

• All data is manually curated rather than computationally extracted
• A three-tiered QC process is applied to every data set
• Quality management is certified to QMS-ISO-9001:2015 standards
• Curation capacity is up to 24 molecules per day
• Turnaround time can be as short as 48 hours depending on scope

Delivery and Ongoing Support

• Data is delivered in XLS, CSV, or TSV file formats
• Clients can request periodic data updates after initial delivery
• Pricing is determined by the scope and scale of the requested data set

Documented Use Case

• An AI drug discovery company used GOSTAR™ Large Molecules to obtain structured and annotated antibody sequence and target affinity data
• The data was used to build training datasets for AI and machine learning algorithms targeting precision medicine applications
• Analysis of antibody affinity data enabled the client to identify antibodies with polypharmacology beyond their primary indication, supporting investigation of antibody repurposing opportunities

GOSTAR™ Large Molecules is offered by Excelra, which maintains offices across the United States, United Kingdom, Belgium, Netherlands, and India. The product sits within Excelra's broader GOSTAR™ SAR database portfolio, which also includes offerings for small molecules and targeted protein degradation (TPD).