Enrollment Forecaster

ProofPilot's Enrollment Forecaster is a Planning Module designed to help clinical trial sponsors replace manual, time-consuming feasibility processes with fast, accurate, AI-powered enrollment predictions. Built on proprietary data from over 500,000 trials and powered by Generative AI, Machine Learning, and Causal AI, the tool enables sponsors to configure likely scenarios, proactively map out risks, and move forward with confidence — reducing what typically takes five weeks of feasibility work down to just five minutes.

The Enrollment Forecaster is part of ProofPilot's broader Clinical Trial Experience Platform, which centralises and simplifies recruitment, conduct, and communication for sponsors, patients, and sites across the entire clinical trial lifecycle. It is particularly suited to pharmaceutical sponsors and clinical operations teams seeking to eliminate guesswork and improve the predictability of study timelines.

Core Forecasting Capabilities

• Forecast with precision down to the site level, modelling site activation, screen failures, discontinuation rates, and non-enrolling sites
• Forecasts adapt by country, region, and indication to reflect real-world variability
• Quantify uncertainty through confidence intervals and scenario comparisons built from real-world trial data and Monte Carlo simulations
• Measure and mitigate risk rather than simply projecting outcomes
• Adjust forecasts in real time to reflect protocol amendments, eligibility criteria changes, or country swaps — without restarting from scratch

Scenario Modeling

• Model complex enrollment structures and "what if" scenarios
• Configure scenarios by key dates, rates, and pauses to reflect a wide range of planning conditions
• Explore multiple plausible futures simultaneously to support proactive decision-making

Enrollment Simulation

• Over 100 simulations conducted instantaneously
• View trial performance across country, site, and overall study levels
• Gain a comprehensive picture of how enrollment is likely to play out under different conditions

Multi-Level Planning

• Create plans at global, regional, country, and site levels
• Generate unique projections down to the individual site level for granular visibility
• Support coordinated planning across complex, multi-country trial structures

Benchmark Dataset

• Powered by proprietary data drawn from over 500,000 clinical trials
• Provides a robust, real-world foundation for all forecasts and simulations
• Designed to ensure a user-friendly experience that promotes engagement across sponsor teams

The Enrollment Forecaster integrates within the wider ProofPilot platform, which also encompasses site activation, staff training, document exchange, patient and site engagement, clinical trial websites, recruitment technology, and analytics tools including sponsor dashboards and recruitment analysis. Clients including top-10 and top-20 pharma companies have reported significant improvements in trial timelines, compliance, and operational efficiency when using ProofPilot's suite of solutions.