ChatRWD

ChatRWD® is a generative AI application developed by Atropos Health that produces full observational studies on healthcare data through a chat-based interface. It is designed for users in healthcare and life sciences who need publication-grade real-world evidence (RWE) generated in minutes rather than months, replacing lengthy traditional research workflows with a conversational Q&A process.

ChatRWD combines a generative AI chat interface with Atropos Health's established technologies for rapid RWE generation. Users can pose a clinical question or protocol and receive detailed refinement suggestions, descriptive statistics, and publication-grade evidence within minutes. The tool draws on the same methodology behind Atropos Health's Green Button® Informatics Consult Service, which has been used to generate and publish Prognostograms for over ten years.

Key Capabilities

• Generates full observational studies on structured, selected healthcare datasets in minutes based on a user-entered question.
• Delivers detailed refinement suggestions in seconds, descriptive statistics within approximately one minute, and publication-grade RWE shortly after.
• Supports a stepwise refinement process, allowing users to iteratively hone in on the most relevant findings.
• Produces Prognostograms that meet expected publication criteria, including supporting methods, charts, figures, abstracts, and summaries.
• Allows users to select the dataset on which the observational study is run.

Performance Benchmarks

• ChatRWD outperformed all other large language models (LLMs) tested, completing more answers — achieving an 88% completion rate.
• Independent physician reviewers rated ChatRWD as producing the best answer on 60% of clinical questions evaluated, and found 44% of answers trustworthy enough to inform clinical practice.
• ChatRWD provided answers backed by evidence 58% of the time; the next closest LLM, OpenEvidence, achieved 24%, while other LLMs were at or below 10%.

Intended Users and Use Cases

• Healthcare and life sciences professionals requiring rapid real-world evidence generation.
• Teams working in HEOR, Medical Affairs, and RWE who need publication-grade outputs on short timelines.
• Research and development, brand planning, precision medicine, and commercial analytics functions within life sciences organizations.
• Health system stakeholders in pharmacy, research informatics, value-based care, quality, and graduate medical education (GME).

ChatRWD is part of Atropos Health's broader suite of automation solutions, which also includes the Atropos Evidence™ Agent, Green Button®, and Forge®. It operates in conjunction with Atropos Health's data infrastructure, including the GENEVA OS® and the Atropos Evidence™ Network, and is positioned as a standalone access point for users seeking to generate evidence directly from healthcare data without requiring deep technical expertise.