Ankyras

Ankyras® is a clinical support application developed by Mentice for braided device sizing assessment in the treatment of intracranial aneurysms. Designed exclusively for qualified medical professionals, it predicts flow diverter (FD) foreshortening and final positioning with 94% average accuracy, enabling patient-specific treatment planning with a high degree of precision and predictability. The solution is available on Desktop, Web, and Mobile platforms, providing a user-friendly interface that promotes seamless communication between healthcare professionals and device manufacturers.

Backed by a robust algorithm and validated across more than 130 retrospective patient cases, Ankyras delivers highly detailed anatomical information and simulates desired flow diverters within the target vessel. It achieves 94% average accuracy in final flow diverter length and proximal landing position, and 90% average accuracy in flow diverter wall apposition and local porosity, making it a clinically reliable tool for neurovascular intervention planning.

Key Features and Benefits

• Accurate visualization of device foreshortening and final position within the patient's vasculature
• Unique foreshortening algorithm enabling simulation and comparison of multiple flow diverter sizes to identify the most suitable device for each patient
• Assessment of stent-wall apposition and local porosity for detailed investigation of different flow diverters
• Flow diverter telescoping functionality for the management of complex cases
• Vessel morphology characterization of the aneurysm region
• Ability to share simulation results through an online portal, enabling collaboration between physicians, device manufacturers, and distributors
• Seamless workflow with direct image transfer from the cath lab to Ankyras via a DICOM node, eliminating manual steps and accelerating clinical decision-making
• Physicians can interact with vessel curves, shapes, and push zones to help define the best treatment strategy for each patient

DICOM Node Integration

• Enables seamless, automated DICOM transfer from angiography systems directly to the Ankyras desktop environment
• Provides real-time access to neurovascular imaging within the cath lab setting
• Eliminates manual data handling steps, optimising workflow efficiency and supporting precise, patient-specific analysis without delays

Four-Step Sizing Workflow

1. Import/Upload Data: Load DICOM images and/or 3D surface models from the patient's vasculature using a simple-to-use module, either via direct transfer from the cath lab through the DICOM node or by uploading through the Ankyras online module.
2. Simulate: Access a multi-faceted simulation environment via desktop, web, or mobile. The workflow is run before the intervention using diagnostic 3D images and can be brought into the operating room on standard mobile devices, offering convenience and immediate access ranging from pure visualization to complete workflow control.
3. Device Sizing Selection: Simulate desired flow diverter devices using the unique foreshortening algorithm and compare results across different sizes to predict the most suitable device and distal position for optimal flow diversion effect.
4. Simulation Sharing (Web): Once the simulated device deployment is saved, share results with manufacturers, distributors, and clinicians for pre- or post-operative case planning and collaborative decision-making.

Clinical Validation

• Validated with more than 130 retrospective patient cases
• 94% average accuracy in final flow diverter length and proximal landing position
• 90% average accuracy in flow diverter wall apposition and local porosity
• Supported by multiple published validation studies and research papers

Ankyras is manufactured by Mentice Spain S.L., which holds ISO 13485 certification. The product is CE marked under MDR, holds UKCA certification, is 510(k) cleared by the FDA (K230006), and is notified to ANVISA. As an add-on to the NV Connect platform, Ankyras benefits from Mentice's over 25 years of experience integrating virtual and physical platforms for medical device and procedural training, including online simulations and direct communication channels between manufacturers and clinical users for patient-specific treatment discussion and device feedback.