Novasign

Novasign is an Austrian bioprocess development software and services company that streamlines the design, optimization, and control of bioprocesses through advanced machine learning, hybrid modeling, and digital twin technologies. The platform is purpose-built to reduce experimental workload and accelerate development timelines, enabling clients to bring robust processes to market faster and with greater confidence.

Novasign serves a diverse range of industries including biopharmaceuticals, enzyme manufacturing, cultured food production, and academic research. The company combines deep expertise in bioprocessing, process modeling, and software development to deliver a unique end-to-end workflow — from experimental planning through to full-fledged automated process control. Novasign has established partnerships with leading organizations such as Repligen to further advance bioprocessing digitalization.

Core Platform Capabilities

• Hybrid Modeling Toolbox: Applies state-of-the-art machine learning algorithms in a streamlined workflow to understand and optimize every bioprocess unit operation, as well as the full end-to-end process chain.
• Smart Experimental Planning: Reduces experimental workload by up to 70% by combining intelligent experimental design with hybrid modeling, significantly accelerating development timelines.
• Automated Data Alignment: Minimizes workload in data preprocessing to create a solid foundation for follow-up process modeling.
• Digital Twin: Enables real-time visualization of bioprocesses and supports advanced process control for both upstream and downstream operations.
• PAT-Driven Insights and Autonomous Process Control: Integrates process analytics with model predictive control to unlock autonomous optimization across all unit operations, including continuous manufacturing applications.

Upstream and Downstream Coverage

• Upstream Development and Optimization: Smart workflows reduce experimental effort by up to 70%, optimizing upstream processes from development through to manufacturing, covering process optimization and media development.
• Downstream Processing: Workflows support key downstream unit operations including dead-end filtration, UF/DF, SPTFF, chromatography, and formulation.
• Scale-Up and Tech Transfer: De-risks scale-up from lab to manufacturing scale across diverse bioreactor geometries and operational modes, including process economics considerations.

Contract Research Services

• Novasign's bioprocess modeling experts can perform experiments on behalf of clients to optimize processes or investigate process behavior using scale-down models.
• Services are applicable across pharma, enzyme manufacturing, cultured food, and academic research sectors.

Notable Customers and Collaborations

• FH Campus Wien: Novasign's software has been embedded into the university's educational program to digitize microbial fermentation processes, giving students hands-on experience building digital twins from real-world experiments.
• Bisy GmbH: A proof-of-concept study with Novasign reduced development time by more than 50%.
• Takeda: Novasign successfully developed new process models by rapidly familiarizing themselves with new process technology details.
• Arkeon: Since 2022, Novasign has supported Arkeon in refining workflows through hybrid modeling and digital twins, achieving deeper process understanding with reduced experimental requirements.

By combining software innovation with hands-on bioprocessing expertise, Novasign empowers organizations across the life sciences and food technology sectors to maximize efficiency, reduce time-to-market, and achieve robust, scalable bioprocesses.