Complete Genomics

Complete Genomics is a pioneering global life sciences company headquartered in San Jose, California, dedicated to driving genomics forward through complete, end-to-end next-generation sequencing (NGS) solutions. Founded in June 2005, the company has spent nearly two decades developing and manufacturing a full spectrum of genetic sequencing instruments, reagents, lab automation tools, and analysis software — empowering researchers, healthcare professionals, and industrial scientists to unlock the unlimited potential of genomic data. Complete Genomics' mission is to change the way genomics is approached today in order to improve human lives tomorrow, with a strong focus on making cost-effective genomics broadly accessible.

The company serves a wide range of customers across research, healthcare, and industrial applications, offering solutions that span every step of the genomic workflow — from sample extraction and library preparation through sequencing and downstream bioinformatic analysis. Complete Genomics operates a state-of-the-art demo lab at its San Jose headquarters, where customers can experience its cutting-edge sequencers and lab automation equipment firsthand.

Proprietary DNBSEQ™ Technology

• Complete Genomics' core sequencing technology, DNBSEQ™, is built on rolling circle replication (RCR), enabling real PCR-free next-generation sequencing with exceptional accuracy.
• Accuracy: RCR eliminates clonal error and index hopping, delivering unrivaled sequencing accuracy compared to conventional approaches.
• Cost-effectiveness: The combination of RCR and a high-density patterned array results in a low duplication rate, reducing overall sequencing costs. Flow cell loading does not require expensive DNA quantification instruments or reagents.
• Efficiency: RCR is completed prior to loading onto the array or flow cell, removing time-consuming and costly DNA quantification steps from the workflow.
• The technology supports a broad range of applications including whole genome sequencing (WGS), haplotype-phased WGS, spatial omics, single-cell RNA sequencing, and spatial transcriptomics.

Sequencing Platforms

• DNBSEQ-G99: The fastest sequencer in the portfolio, delivering up to 48 Gb of data in less than 12 hours, with the ability to run two independent flow cells simultaneously.
• DNBSEQ-G400 FluoXpert: A multi-omics sequencer capable of performing genomics, transcriptomics, and proteomics within a single integrated system.
• DNBSEQ-T1+: An all-in-one mid-throughput sequencer featuring Q40 quality scores, generating between 25 Gb and 1.2 Tb of data in under 24 hours.
• DNBSEQ-T7+: A large-scale, high-throughput sequencer capable of generating more than 14 Tb of data and sequencing up to 35,000 whole genomes per day.

Kits, Reagents, and Lab Automation

• Complete Genomics offers a comprehensive range of kits and reagents designed for ease of use and seamless integration into existing workflows.
• Conversion kits are available for third-party library preparation compatibility, broadening the platform's flexibility.
• Lab automation solutions cover the full range from sample extraction through to sequencing setup, reducing hands-on time and allowing researchers to focus on higher-value activities.

Software and Analysis

• Proprietary algorithms are built directly into each sequencer, providing secure, fast, and accurate sequencing read processing at the instrument level.
• Software and analysis tools are designed to complement the full sequencing workflow, supporting applications such as complete WGS, single-cell RNA sequencing, and spatial transcriptomics.

Spatial Transcriptomics — Stereo-seq Technology

• In addition to DNBSEQ™, Complete Genomics offers Stereo-seq technology for spatial transcriptomics applications, enabling spatially resolved gene expression analysis.
• Spatial technology products are available as a dedicated product category, complementing the company's broader NGS portfolio.

Company Values and Vision

• Bold: Committed to the relentless pursuit of accessible genomic solutions that change the face of the field.
• Proactive: Continuously working on the next innovation to drive genomics forward.
• Connected: Focused on building strong partnerships and contributing to the greater good of human health.
• Complete: Striving to deliver not just individual products, but comprehensive, integrated solutions that empower researchers with the efficiency they need.

Complete Genomics products are intended for research use only and are not for use in diagnostic procedures. The company continues to expand its portfolio and engage the scientific community through educational resources, webinars, and events — including clinical WGS-focused programming — reinforcing its position as a comprehensive partner for genomic research worldwide.