Selector

Genedata Selector is designed to integrate and analyze next-generation sequencing (NGS) data, facilitating collaboration and efficient result sharing with full transparency and traceability. It supports organizations like Octapharma by providing analytical capabilities that cater to users of all expertise levels. The platform includes ready-to-use Playbooks, an intuitive genome viewer, and customized workflows, enhancing data processing efficiency and organizational collaboration.

Octapharma utilizes Genedata Selector to optimize the handling and analysis of NGS data, crucial for the in-depth characterization of engineered production cell lines. This approach is essential for complex projects requiring high-quality results and versatile applications.

Customer Success Stories

At Boehringer Ingelheim, Genedata Selector has been instrumental in various projects. RNA-seq is used as an alternative to Sanger sequencing, offering superior sensitivity for mutation detection and scalability for up to 96 samples per batch. This method allows for automatic bioinformatic analysis, enhancing specificity, repeatability, and robustness.

In another case, Boehringer Ingelheim scientists used NGS to identify the root cause of unusual recombinant protein characteristics by examining genomic and transcriptomic changes. This deep dive into cell line phenotypes was crucial for understanding differences at the genetic level.

Furthermore, Genedata Selector facilitated the localization and structural characterization of random transgene integration in CHO manufacturing clones. This analysis helped assess performance characteristics, such as viability and antibody titers, and provided critical insights into cell stability.

In a case study, innovative cell line development approaches, combined with digital technology, enabled the rapid production of GMP-grade antibody-based therapeutics. This accelerated process allowed for the manufacturing of high-quality drug substances at a commercial scale in less than three months.

Key Features and Benefits

• Centralized genome knowledge management and analysis solution.
• Supports interdisciplinary challenges in next-generation biotechnology innovations.
• Facilitates the integration of complex R&D-relevant data, making it accessible globally.
• Enhances quality control and cell line development workflows by increasing the number of clones analyzed.

Genedata Selector is likened to a well-organized library, where data can be easily and quickly accessed, supporting efficient research and development processes.