PBPK Modeling and Simulation

Physiologically Based Pharmacokinetic (PBPK) modeling and simulation is a dynamic approach that integrates drug properties with species physiology to simulate drug concentration in plasma and tissues. This method provides a comprehensive, data-driven approach that enhances decision-making, optimizes resources, and reduces drug discovery and development risks.

• Early prediction of human PK and dose
• Optimization of drug formulations
• Assessment of developability potential and risk mitigation strategies
• Supports the design and conduct of required experiments
• Predicts drug behaviour across populations
• Enhances regulatory support and translational PKPD studies
• Accelerates time-to-market and maximizes use of preclinical data
• Early DDI evaluation of drug candidates