Maestro ZHT

The Maestro ZHT is a high-throughput live-cell analysis platform designed to measure cellular behaviors such as proliferation, death, morphology, and attachment in a label-free and real-time manner. This system is capable of accommodating both 96-well and 384-well plate formats, providing robust data without the need for multiple endpoint assays.

The platform uses electrical impedance to continuously capture the full cellular response profile, which allows tracking of cell interactions, cytotoxicity, and drug responses over time. By avoiding the use of dyes and reporters, it eliminates potential disturbances to cell models, offering a clearer understanding of the biological processes.

Key Features

• Simultaneous live recordings from up to 384 wells, allowing comprehensive and noninvasive analysis.
• Integrated environmental control that precisely manages temperature and CO₂ levels, removing the need for an external incubator.
• Automated experiment setup with one-button start, including intuitive plate tracking via barcode scanning.
• GxP Impedance Module available for compliance with FDA 21 CFR Part 11 in GLP/GMP labs, ensuring assays are fully auditable.

Furthermore, the Maestro ZHT is compatible with cross-platform use, enabling live-cell imaging along with real-time functional data. It supports enhanced analysis by monitoring electrode coverage and cell morphology.

The system is further designed for high-throughput screening validation, demonstrating efficiency without edge effects, achieving a high Z' factor.

Users can monitor experiments remotely via the Maestro Z App, and multiple units can be managed from a single computer interface, optimizing lab space and resources.

The versatile application of Maestro ZHT includes evaluating antiviral effects, monitoring cell barrier integrity, studying tumor biology, tracking immune cell activity, and assessing GPCR signaling dynamics. Its avid compatibility with various assays enriches assay multiplexing capabilities.