AutoChrom

AutoChrom is a comprehensive software solution designed for chromatography experts to develop chromatographic methods efficiently using Quality by Design (QbD) principles. It provides a structured workflow to streamline and manage projects, starting from initial conditions and column selection to strategy implementation with the aid of software wizards and assistants.

The software automates the execution of experiments for screening and optimization, allowing users to model separations in one, two, or three dimensions. It also facilitates documentation of decision-making processes and stores projects in a searchable database for future reference.

Key Benefits

• Project Management: Manage your project from inception to documentation, ensuring data integrity and easy retrieval from a searchable database.
• Automation: Automate screening and optimization trials, enabling unattended operation and efficient experiment execution.
• Simulation and Optimization: Use simulation to optimize separations in 1D, 2D, or 3D with color-coded resolution and suitability maps, reducing unnecessary experiments.
• Peak Tracking: Algorithmically track peaks across multiple chromatograms using UV or MS spectra, simplifying the process with advanced algorithms.

AutoChrom offers a dashboard view of projects, displaying workflow strategies, experimental steps, and instrument configurations. It allows users to find optimal conditions by predicting logD for various pH levels and provides tools for peak matching and column selection using radar graphs.

Features

• Workflow Management: Build workflows for screening, optimization, and robustness studies, setting parameters like solvent ratio, column, pH, gradient, and temperature.
• Modeling: Simulate resolution maps in 1D, 2D, or 3D, customize equations, and evaluate modeling accuracy by comparing experimental and modeled results.
• Separation Optimization: Optimize LC separation parameters and visualize suitability criteria across the design space.
• Retention-Time Prediction: Predict retention times for new compounds and manage data transfer with AutoChrom Online or manually with AutoChrom Offline.

AutoChrom integrates with various chromatography data systems for seamless experiment execution and supports a wide range of instruments and techniques. It enhances method development by connecting strategy to experiments, documenting choices, and optimizing outcomes efficiently.