Synthace Discovery

Synthace Discovery is a purpose-built software platform designed to help scientists design, execute, and analyze automated, high-dimensional experiments — all in one place. Built with drug discovery in mind, it enables both individual scientists and teams to tackle complex experimental challenges faster and with greater confidence, without requiring deep expertise in statistics or automation programming.

The platform supports powerful multivariate experimental approaches such as Design of Experiments (DOE) and High-Dimensional Experimentation (HDE), addressing the key pain points that arise when using generic statistical software in a discovery biology context. Synthace Discovery is already in use across labs worldwide, with proven results at organizations including Charles River Laboratories, Oxford Biomedica, and Innocent Meat.

How Synthace Discovery Works: 5 Steps to Better Experiments

1. Design: Scientists select their factors and levels, and Synthace Discovery guides them in choosing the best experimental design suited to life sciences — no advanced statistical expertise required.
2. Plan: Users easily describe all steps in their experiment, including plate layouts, volumes, order of addition, and incubation conditions. The platform handles all the underlying calculations automatically.
3. Execute: Synthace Discovery simulates every transfer within a DOE or HDE design, providing clear visualizations of what is happening at each step. It creates a digital copy of the experiment and integrates with multiple automated dispensers to generate device instructions automatically.
4. Structure: Experimental data and metadata are automatically structured and aligned, eliminating hours of manual spreadsheet processing. A complete digital record of every run is maintained, with full control over which datasets are included in response analysis.
5. Analyze: Users can quickly calculate values such as XD50s or Z' factor and use them as responses to build models in just a few clicks. Summary analysis can be performed on chosen models without the need for complex external statistical software.

Key Capabilities of Synthace Discovery

• Guided DOE and HDE design workflows that adapt as experiments iterate or as intent and context evolve.
• Easy definition of experimental methods tailored to discovery biology, including support for Dose Response Curves.
• Automatic conversion of experimental designs into device instructions through integration with key automated liquid dispensers.
• Automated structuring and analysis of experimental data and metadata, replacing error-prone manual spreadsheet workflows.
• A complete digital record of every experimental run, with user control over dataset inclusion in response analysis.
• Guided data processing, model building, and analysis presented without overwhelming statistical jargon.

How Synthace Discovery Compares to Generic Statistical Software

• Generic tools require scientists to be statistics experts and offer designs not optimized for discovery sciences; Synthace Discovery provides guided, life-sciences-appropriate designs accessible to all scientists.
• Without Synthace, experimental designs must be manually converted into pipetting actions and are only validated at execution, leading to costly errors; Synthace automates this conversion and enables upfront simulation.
• Programming automation with generic tools is complex and time-intensive; Synthace Discovery integrates directly with dispensers to generate automation instructions automatically.
• Aligning thousands of data points across spreadsheets is time-consuming and error-prone without Synthace; the platform structures and aligns all data and metadata automatically.
• Generic statistics tools can be difficult to interpret and are not tailored to discovery sciences; Synthace Discovery offers guided, jargon-free model building and analysis.

Synthace Discovery is deployed in labs across the world and has been validated in real-world discovery and development settings, including assay optimization in 1536-well plates, DOE-driven process development, and iPSC media optimization. The platform is designed to integrate seamlessly into existing laboratory workflows through its connections with automated dispensing hardware.