Site Explorer

Site Explorer is a clinical trial site selection and protocol optimization tool developed by Verana Health. It is designed for life sciences companies and contract research organizations (CROs) seeking to identify suitable trial sites and build study cohorts using real-world data (RWD). The tool draws on exclusive access to EHR-derived data from two major specialty registries: the American Academy of Ophthalmology (AAO) IRIS® Registry (Intelligent Research in Sight) and the American Urological Association (AUA) AQUA® Registry, covering ophthalmology and urology respectively.

The IRIS Registry contains data on approximately 80 million de-identified patients contributed by around 15,000 clinicians, while the AQUA Registry covers over 13 million de-identified patients from more than 3,800 clinicians. Site Explorer provides access to this data to support site identification, participant eligibility assessment, and protocol optimization decisions.

Core Capabilities

• Builds study cohorts and identifies trial sites based on inclusion and exclusion (I/E) criteria in minutes.
• Provides access to de-identified patient data at scale across both the IRIS and AQUA registries.
• Supplies practice-level information including clinical trial history broken down to the indication level, participant demographics, and site-specific research contacts.
• Supports multiple ophthalmology and urology indications with deep trial experience insights.
• Delivers monthly data refreshes to ensure site and participant information remains current and accurate.
• Combines clinical outcomes data, trial experience records, and practice-level contacts to support site selection decisions.
• Identifies potential referral sources and supports access to diverse patient populations.

Features Supporting Protocol Optimization

• Enables data-driven rescue strategies to address trial challenges such as adverse events or low patient retention.
• Provides regularly updated, clinically rich EHR data sourced exclusively from the IRIS Registry, offering insights not available through other data sources.
• Allows users to view de-identified patient data at scale to assess site suitability before engagement.
• Supports informed adjustments to ongoing trials by leveraging RWD to respond to emerging challenges.

Use Cases by User Type

• Sponsors: Can quickly identify and connect with practices that have a high volume of eligible participants matching trial I/E criteria, and implement data-driven strategies to prevent trial failures.
• CROs: Can use Site Explorer to demonstrate a data-driven approach to protocol optimization and site selection when engaging sponsors, accelerate responses to RFPs, and provide detailed estimates of practice and patient counts to strengthen proposals.

Site Explorer was launched in June 2023. The tool operates using de-identified patient data and is positioned for use across the clinical trial planning and execution lifecycle, with particular depth in ophthalmology and urology therapeutic areas.