Mnova RM

Mnova RM (Reaction Monitoring) is a software plugin from Mestrelab designed to extract dynamic properties from chemical reactions using arrayed NMR datasets. It enables researchers to collect NMR spectra at regular intervals throughout the course of a chemical reaction, transforming raw spectral data into actionable kinetic information. The tool is aimed at organic chemists, process chemists, medicinal chemists, and QC experts working in academic, government, and industrial settings.

Mnova RM is built for fast analysis of complex reactions and large data files, offering flexible data import, processing, and analysis capabilities alongside excellent spectral processing tools. It integrates seamlessly within the broader Mnova software ecosystem, complementing products such as Mnova Core NMR and Chrom Reaction Optimization.

Kinetic Curve Generation

• Provides an intuitive environment to analyze reaction data as concentration versus time.
• Separates raw data for kinetic analysis, using acquisition times as the x-axis.
• Includes dedicated tools for handling poor baselines, phase changes, and interfering signals.
• Uses Global Spectral Deconvolution (GSD) for challenging peak area determination.
• Allows spectral arrays to be refined through reprocessing.
• Supports quick fitting of kinetic data points to mathematical functions, including efficient exponential fitting.

Real-Time Reaction Monitoring

• Fully automated reaction monitoring analyzes datasets and reports all kinetic parameters and reaction endpoints immediately after data acquisition.
• Results are automatically saved to a predefined folder without user intervention.
• Each new spectrum acquired updates the existing analysis, curve fitting, and component concentration tracking in real time.
• A simple graphical interface allows Real-time RM analysis to be set up in minutes, requiring no specific expertise.
• Automates currently time-consuming reaction monitoring workflows end-to-end.

Spectral Processing Capabilities

• Autophase correction for automated phase adjustment across spectral arrays.
• Peak alignment tools to ensure consistency across time-series spectra.
• Robust handling of complex spectral challenges such as baseline issues and overlapping signals.

Mnova RM is available as part of the Mnova platform, with a 45-day free trial available for download. Version 17.0.0 supports Windows, macOS, and multiple Linux distributions including Debian 13, RHEL 8/9/10, Ubuntu 22.04/24.04, and AppImage formats.