MindWalk

The MindWalk Biointelligence Ecosystem, powered by LensAI, is an all-in-one platform that integrates AI, deep biological data, and advanced laboratory research to accelerate biologics discovery and development. Designed for drug discovery teams working across therapeutic antibodies, anti-drug antibodies, diagnostics, vaccines, nanobodies, and peptide therapeutics, the platform is built to make complex biology more computable and actionable — from target identification through to the clinic.

Because no two programs are the same, the MindWalk ecosystem is fully customizable, adapting to different targets, modalities, and program priorities. With more than 15 molecules advanced to the clinic and validated partnerships with organizations including Acumen Pharmaceuticals, GentiBio, OncoResponse, and Amyl Therapeutics, MindWalk combines the expertise of technologists and scientists working side by side to deliver integrated discovery solutions.

Core Platform Capabilities

• Bio-Native AI (LensAI): LensAI is built to interpret biology from the ground up, connecting molecular, structural, and functional data to support clearer understanding across complex biological systems. Unlike models simply trained on data, LensAI links sequence, structure, function, and literature to generate deeper, contextually grounded biological insight.
• Deep Data Integration via HYFT® Technology: HYFTs® organize more than 25 billion biological relationships within LensAI, transforming previously siloed data into connected, discovery-ready insight. HYFT technology has also been applied to detect functional adjacency linked to portfolio risk in AI-designed therapeutics.
• Advanced Lab Research: MindWalk's laboratory capabilities combine experimentation with computational analysis, supporting stronger program starts, deeper biological context, and more informed progression toward the clinic. Lab work is closely integrated with LensAI analysis to generate diverse, high-value leads for partners.

Key Platform Applications and Validated Use Cases

• Nanobody Discovery — B Cell Llama™: A dedicated nanobody discovery platform designed specifically for the bispecific and cell therapy era, enabling discovery of next-generation therapeutic formats.
• Epitope Mapping: LensAI has demonstrated computational insights reaching crystallographic-level accuracy for epitope mapping, strengthening experimental confidence and aligning with x-ray crystallography results.
• Vaccine Design: LensAI identified a highly conserved epitope shared across all four dengue virus serotypes, opening new directions in vaccine design through pattern detection at scale.
• Neurodegenerative Disease: MindWalk validated platform precision with a breakthrough discovery targeting pathogenic TDP-43, demonstrating applicability to challenging neurological targets.
• Pan-Amyloid Immunotherapy: In silico screening, developability analysis, and protein engineering powered by LensAI and HYFT technology accelerated candidate optimization for neurodegenerative disease programs.
• Autoimmunity and Inflammation: Customized antibody discovery approaches combining laboratory expertise and LensAI analysis have been applied to generate specific binders against targets in autoimmunity and inflammation.
• Oncology: The B Cell Select platform supported development of lead immunoinhibitory receptor drug candidates now in Phase I/II clinical trials.

Explainable Intelligence and Discovery Workflows

• LensAI applies explainable intelligence across discovery workflows, ensuring that contextual analysis supports interpretable insight rather than opaque model outputs.
• The CaseXCase series provides a validated collection of results demonstrating how LensAI-driven contextual analysis delivers measurable outcomes across real discovery programs.
• The platform supports iterative workflows, enabling faster cycles of hypothesis generation, experimental validation, and candidate progression.

Therapeutic Modalities Supported

• Therapeutic antibodies and anti-drug antibodies
• Nanobodies and bispecific formats
• Cell therapy applications
• Diagnostics
• Vaccines
• Peptide therapeutics

MindWalk operates as an integrated team of scientists and technologists, offering partnership-based discovery programs supported by both the LensAI platform and in-house advanced laboratory capabilities. The ecosystem is designed to scale across program types and stages, with published scientific posters, case studies, and blog content available to support evaluation of the platform's capabilities and real-world performance.