High Frequency Cognitive Testing

High Frequency Cognitive Testing is a solution from Cambridge Cognition designed to detect fluctuations in cognitive health by administering short cognitive assessment tasks across multiple timepoints. It is intended for use in decentralised and real-world clinical studies, enabling researchers to capture a more realistic picture of cognitive performance by collecting data on a regular, repeated basis rather than at isolated clinic visits.

The solution is built to run on participants' own mobile phones and smart devices, supporting ecological validity by measuring cognition in everyday environments. Each cognitive task takes no longer than four minutes, making the testing burden low while allowing frequent data collection over time.

Core Characteristics

• Short tasks: Individual assessments are delivered at high frequency to enhance detection of day-to-day and over-time fluctuations in cognitive performance.
• Mobile-friendly delivery: Tasks are accessible on participants' own devices, improving accessibility and supporting real-world evidence generation.
• Patient-led testing: Participants complete tasks without researcher or clinician supervision, reducing administration burden and associated costs.

Participant Support Features

• Clear on-screen instructions guide participants through each task independently.
• Voice-over guidance is provided to assist with task completion.
• Automated assistance and troubleshooting are available to support participants without requiring researcher intervention.

Cognitive Domains and Available Tasks

• Attention and psychomotor speed: Psychomotor Vigilance Task (PVT) — approximately 3 minutes.
• Executive function: Cognition Kit Digit Symbol Substitution (DSST) — approximately 90 seconds.
• Emotion and social cognition: Emotional Bias Task (EBT) — approximately 4 minutes.
• Memory: Cognition Kit N-Back (NBX) — approximately 90 seconds.

Study Design Suitability

• Supports remote and decentralised clinical trials where participants are spread across a large geographical area.
• Enables virtual assessment of participants without the need for on-site researcher or clinician administration.
• Collects cognitive function data alongside physiological data and patient-reported outcomes on the participant's own device.
• Allows participants to complete tasks in a comfortable, self-chosen environment without compromising research objectives.

High Frequency Cognitive Testing sits within Cambridge Cognition's broader portfolio of digital cognitive assessment technologies, which also includes CANTAB® and voice-based assessments, and is applicable across a range of therapeutic areas including Alzheimer's disease, depression, Parkinson's disease, schizophrenia, and traumatic brain injury, among others.