East Horizon Platform for Trial Design

The East Horizon™ Platform for Trial Design by Cytel is a comprehensive, unified clinical trial design software platform built for biopharmaceutical sponsors, clinical researchers, and drug development teams. Drawing on four decades of expertise in adaptive trial design, East Horizon™ consolidates industry-leading capabilities into a single seamless solution, empowering users to design, simulate, and optimize clinical study protocols with precision and confidence across all phases of drug development.

Cytel has transitioned from offering standalone software products to delivering a fully integrated platform that brings together adaptive, Frequentist, and Bayesian tools in one environment. This transformation is designed to streamline trial design processes, reduce complexity, and accelerate the path from protocol development to regulatory submission — pushing the boundaries of what is possible in clinical research.

Core Platform Capabilities

• Precise trial design and simulation using adaptive, Frequentist, and Bayesian statistical methodologies
• Optimization of study protocols to increase the probability of trial success throughout the drug lifecycle
• Integration of open-source tools alongside industry-leading proprietary software within a unified platform
• Support for complex and innovative trial designs, including adaptive trial designs
• Tools to accelerate drug development timelines with data-driven decision-making

Platform Approach and Innovation

• Consolidation of previously standalone software products into one comprehensive platform offering broad functionalities
• Built on four decades of pioneering experience in adaptive trial design software
• Designed to unify innovation and operational efficiency within a single integrated environment
• Enables teams to redefine clinical research capabilities through advanced data analytics
• Supports the full drug development cycle, from discovery and Phase I–III clinical trials through to commercialization

Supported Trial Design Methods

• Adaptive trial design, enabling flexible protocol modifications based on interim data
• Bayesian statistical tools for probabilistic inference and decision-making
• Frequentist methods for traditional hypothesis testing and sample size determination
• Complex and innovative trial design approaches tailored to specialized therapeutic areas
• Model-informed drug development (MIDD) methodologies

Therapeutic Areas and Specialty Applications

• Oncology trial design and simulation
• Rare disease study optimization
• Central nervous system (CNS) trials
• Pediatric study design
• Decentralized trial support
• Post-authorization safety studies

Broader Software Ecosystem

• East Horizon™ is part of Cytel's wider software solutions portfolio, which also includes the Xact software suite (StatXact®) for exact statistical analysis and Enforesys for trial implementation and decision support
• Complementary services include strategic consulting, end-to-end biometrics, regulatory strategy, and clinical development planning
• The platform integrates with Cytel's broader data science and analytical methods capabilities to support the full drug development lifecycle

East Horizon™ is positioned as a strategic tool for organizations seeking to craft optimal trial designs with confidence, supported by Cytel's deep expertise in adaptive methodologies, regulatory compliance, and advanced analytics. The platform is suitable for teams across Phase I–III clinical trials and beyond, offering both software capabilities and access to Cytel's broader consulting and delivery services.