DiseaseBank

DiseaseBank™, developed by PrecisionLife, is the world's largest repository of novel proprietary and predictive disease insights, purpose-built to deliver world-leading mechanistic understanding of chronic diseases. It is designed for life sciences organisations seeking to accelerate drug discovery, identify novel therapeutic targets, and develop precision medicine strategies for diseases with significant unmet medical needs.

Drawing on the analysis of data from more than 7 million patients across 60+ completed disease studies, DiseaseBank has uncovered over 400 novel targets and more than 100,000 clinical biomarkers. The platform's science is focused on generating the deepest insights in chronic disease biology, with the goal of driving precision medicine beyond oncology and rare disease into the broader landscape of complex chronic conditions.

Key Statistics and Scale

• Over 60 disease studies completed across major therapeutic areas
• More than 7 million patients' data analysed
• 400+ novel targets discovered
• 100,000+ clinical biomarkers identified

Therapeutic Areas Covered

• Neuropsychiatric: Anxiety and panic disorder, bipolar disorder, major depressive disorder, obsessive compulsive disorder, schizophrenia, and SSRI response
• Neurological: ALS/MND, Alzheimer's disease, epilepsy, frontotemporal dementia, Lewy body dementia, migraine, multiple sclerosis, and Parkinson's disease
• Metabolic: Type-I diabetes, Type-II diabetes complications, chronic kidney disease, MASH/MASLD, and obesity
• Cardiovascular: Atherosclerosis, atrial fibrillation, cardiomyopathy, coronary artery disease, glaucoma, heart failure, and hypertension
• Allergy and Infectious Disease: Acute respiratory distress syndrome, COVID-19, fibromyalgia, long COVID, ME/CFS, and sepsis
• Respiratory: T2 and non-T2 asthma, bronchiectasis, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis
• Women's Health: Adenomyosis, endometriosis, polycystic ovary syndrome, post-partum depression, and uterine fibroids
• Aging: Chronic disease onset and progression, glaucoma, longevity, macular degeneration, and osteoarthritis
• Gastrointestinal: Inflammatory bowel disease, IBS, Crohn's disease, and ulcerative colitis
• Oncology: Breast cancer, breast cancer cardiovascular disease risk, lung cancer, ovarian cancer, and prostate cancer
• Dermatological: Alopecia, atopic dermatitis, and vitiligo
• Auto-immune: Rheumatoid arthritis, Sjögren's disease, systemic lupus erythematosus, and systemic sclerosis

Core Scientific Capabilities

• Generation of deep mechanistic insights into the biology underlying chronic diseases
• Discovery of novel genetic associations, therapeutic targets, and biomarkers
• Support for precision medicine development across a broad range of complex and chronic conditions
• Proprietary and predictive disease insights derived from large-scale patient data analysis

DiseaseBank represents PrecisionLife's commitment to expanding the reach of precision medicine, providing pharmaceutical and biotech organisations with the mechanistic intelligence needed to address some of the most challenging and prevalent diseases affecting billions of patients worldwide.