Custom Biomarker Knowledgebase

The Custom Biomarker Knowledgebase is a database product from Excelra designed for scientists developing biomarker strategies. It addresses the need to harmonize data from research articles and clinical trials into coherent, structured datasets, with the goal of accelerating biomarker discovery and validation, and supporting the design of clinical trial methodologies.

The knowledgebase supports biomarker identification, prioritization, and analysis across disease areas, with specific coverage noted for colorectal cancer and a selection of up to 20 oncology indications including acute lymphoblastic leukemia, breast cancer, non-small cell lung cancer, melanoma, pancreatic cancer, and others.

Core Capabilities

• Maps relationships between biomarkers, diseases, drugs, and clinical outcomes.
• Ranks and prioritizes biomarkers associated with standard-of-care treatments, pipeline drugs, and selected patient cohorts.
• Supports data-driven decisions derived from clinical and exploratory patient sample studies.
• Assesses more than 30 different biomarker-linked outcomes.
• Includes a rigorous content vetting process with biomarker classification and sub-categories.
• Allows users to select relevant studies and drugs, examine cohort demographics, and review drug information.

Data Structure and Depth

• Captures 85 distinct fields in total, drawn from full-text research articles and clinical trials.
• 35 fields capture biomarker-related specification, result, direction, methodology, and outcome.
• 28 fields provide details on study design, cohorts, and demographics.
• 15 fields cover study and drug results.
• 7 fields record inferences.

Disease-Specific Biomarker Insights

• Provides scientific evidence linking biomarkers to specific diseases.
• Colorectal cancer is highlighted as an available indication with detailed biomarker insights.
• Users can select from a list of up to 20 oncology indications of interest, covering a range of solid tumors and hematologic malignancies.

Customization and Collaboration

• The knowledgebase is described as co-designed and co-created with the client team rather than delivered as a fixed, prescriptive solution.
• Excelra works with organizations to tailor the knowledgebase to their specific research and clinical needs.

Excelra maintains offices across the United States, United Kingdom, Belgium, Netherlands, and India. The Custom Biomarker Knowledgebase sits within Excelra's broader portfolio of data science, scientific informatics, and database offerings serving life sciences companies.