Clear Ix

Clear Ix™ is a fully automated, next-generation sequencing (NGS) platform developed by Clear Labs for infectious disease research. Designed to deliver complete characterization of bacterial, fungal, and viral pathogens, it supports both whole genome sequencing (WGS) and targeted NGS (tNGS) across a wide range of applications. Clear Ix™ is built for research laboratories seeking accurate, near real-time results for pathogen characterization and genomic surveillance, and is intended for research use only — not for use in diagnostic procedures.

By consolidating the entire sequencing workflow into a single, walkaway-automated platform, Clear Ix™ dramatically reduces the time, expertise, and manual effort traditionally required for infectious disease genomics. It is suited for laboratory teams of varying technical backgrounds, enabling technologists to focus on other tasks while the instrument handles the sequencing process.

Automation and Workflow Efficiency

• Fully automated liquid handling covers cDNA synthesis, amplification of targets, indexing, nucleic acid clean-up, and sequencing run initiation — with no manual library preparation required.
• Reduces hands-on time from several hours to less than 45 minutes, requiring no genomics expertise from the operator.
• Cuts the number of human touch points from dozens of manual steps down to just one.
• Decreases time to results from next-week turnaround to next-day delivery.
• Enables one seamless solution within a single lab shift, facilitating more timely decision-making during pathogen outbreaks.
• Increases lab technologist productivity by allowing staff to perform other tasks after loading samples onto the instrument.

Consistent and Reliable Results

• Generates reproducible outcomes repeatedly, reducing workflow errors and increasing result consistency.
• Boosts overall productivity and improves an organization's genomic surveillance capabilities.
• Connects insights with unparalleled speed and precision through pathogen sequencing automation.
• Produces accurate test results that laboratories can act on with confidence.

Streamlined Data Management and Bioinformatics

• Comprehensive workflow allows users to manage and interpret genomic data without the need for dedicated bioinformatics specialists.
• Features data integration and connectivity solutions designed to streamline genomic surveillance operations.
• Places high priority on protecting the integrity and availability of customer data through secure software infrastructure.
• Open API integration is available, along with sequencing files and quality metrics for each sample, downloadable after analysis.
• Intuitive software interface enables simplified sample registration and result analysis, minimizing manual, error-prone interaction.

Supported Applications

• Clear Ix™ Microbial ID tNGS — Targeted 16S and ITS Sequencing: Quickly detects multiple bacteria and/or fungi that are difficult to culture from disease research specimens.
• Clear Ix™ Deeplex® Myc-TB — Targeted Mycobacterium Sequencing: Rapidly characterizes over 150 Mycobacterium species and MTB drug resistance from isolates or sputum DNA extracts.
• Clear Ix™ Microbial Surveillance WGS — Whole Genome Sequencing: Automates the entire WGS process for bacteria, fungi, and viruses from isolates or extracted nucleic acid, with flexible workflow options supporting a wide range of input concentrations, with or without nucleic acid extraction.
• Clear Ix™ WGS SARS-CoV-2 — Public Health Specimens: Provides fully automated whole genome sequencing of RNA extracts with assembled FASTA files, utilizing long-read sequencing technology.
• Clear Ix™ FlexPro: Wastewater (SARS-CoV-2): Delivers fully automated whole genome sequencing of SARS-CoV-2 RNA extracts from wastewater samples using short-read sequencing technology.

Clear Ix™ is available for implementation at laboratory facilities through purchase and lease arrangements. Technical resources including white papers, platform overviews, and technical notes are available to support evaluation and deployment of the platform.