Central eSource

Central eSource is a clinical trial data collection system developed by CRIO, designed for sponsors and CROs who want to standardize source data capture across multiple study sites. It addresses a common problem in clinical trials where sites independently create source templates, collect data in disparate systems, and manually transcribe records into an electronic data capture (EDC) system — a process that introduces errors, delays, and inconsistencies.

CRIO Central eSource works by allowing sponsors or CROs to develop a single, centralized source template that is published to all participating sites. Sites can configure the template to meet local requirements while keeping core data fields intact. According to CRIO, this approach results in 40% higher enrollment, 40% faster time to EDC entry, 20% fewer protocol deviations, and a 90% increase in monitoring productivity.

How Central eSource Differs from Standard eSource Approaches

• Without Central eSource, different protocol interpretations lead to variations in source templates and data collection across sites.
• Sites typically must build entire source templates themselves, slowing study startup.
• Manual EDC entry introduces errors and requires sponsors and CROs to perform source data verification (SDV).
• Data is collected through a mix of mechanisms with inconsistent accessibility for sponsors and CROs.
• With Central eSource, one centralized template ensures key safety and endpoint data are captured consistently across all sites.
• Templates include standardized key data points but remain configurable by sites to fit their local processes.
• Pre-mapped eSource variables feed data directly into the EDC, eliminating manual transcription.
• Sponsors and CROs have real-time, fully remote access to source data across all sites.

Core Features

• eSource to EDC Data Flow: Integrates with CRIO's native Reviewer EDC system or third-party EDC systems to eliminate manual transcription and SDV.
• Reporting: Includes a suite of standard reports, a flexible in-platform report creation tool, a custom report development service, and direct data access for use with external business intelligence tools.
• Publishing: Supports centralized creation, management, and publishing of eSource templates across multiple sites.
• Remote Monitoring: Uses a dual database architecture that provides real-time data access for sponsors and CROs while protecting protected health information (PHI).
• Customer Service: Provides site onboarding and training through a site enablement team, along with 24/7 live chat support and dedicated resources to keep studies on track after startup.

Deployment and Site Adoption

• Central eSource is built on the same eSource technology already used by clinical trial sites, allowing sponsors and CROs to leverage existing site familiarity with the CRIO platform.
• The system is available across multiple geographic regions, including the United States, Canada, Australia, and the European Union.
• Sites retain the ability to configure centrally published templates to comply with local requirements without altering core data fields.

Central eSource is positioned for use in multi-site clinical trials where data consistency, remote monitoring access, and reduced site administrative burden are priorities. Its integration options span both CRIO's native EDC and third-party EDC systems, and its reporting infrastructure supports both in-platform analysis and external business intelligence tools.