CAS Chemical Compliance Index

CAS Chemical Compliance Index™ is a comprehensive regulatory intelligence platform designed to serve as a single, authoritative source for global chemical compliance information. Built for regulatory affairs professionals, manufacturers, scientists, and enterprises operating across international markets, it delivers accurate and up-to-date regulatory data to help organisations navigate an increasingly complex global regulatory landscape.

Developed by CAS — a trusted authority on chemical data for more than 100 years — the platform is powered by the CAS Content Collection™, the largest human-curated collection of scientific data in the world. CAS has been contracted by the U.S. Environmental Protection Agency (EPA), as well as European and Canadian government entities, to build regulated substance inventories, and continues to maintain the EPA's TSCA Master Inventory to this day.

Core Capabilities

• Access to more than 150 international regulatory inventories and lists, updated on a weekly basis to ensure currency and accuracy
• Search functionality by CAS Registry Number®, chemical substances, regulatory lists, UVCB descriptions, and more through an intuitive interface
• Substance component search function enabling exploration of regulations for polymeric materials
• Toxicity and ecotoxicity information to support responsible and sustainable decision-making
• Custom alert notifications and pre-manufacturing notices to keep teams informed of regulatory changes

Why Chemical Regulatory Compliance Matters

• Regulatory noncompliance carries financial, environmental, and reputational risks that extend well beyond fines and operational delays
• An increasingly environmentally conscious consumer base means companies must demonstrate genuine commitment to compliance as part of corporate citizenship
• CAS Chemical Compliance Index helps organisations avoid noncompliance fees, ecological incidents, and public relations issues by providing reliable, globally sourced regulatory data
• All regulatory information is consolidated in one place, making it easy to interpret and act upon — as noted by compliance regulatory professionals at large enterprise organisations

Key Use Cases and Applications

• Data validation for risk assessments, supporting thorough and defensible compliance evaluations
• Polymer and polymeric material regulatory searches using the substance component search feature
• Research and development support, including insights into sustainable chemistry and emerging materials
• Ongoing regulatory monitoring through custom alerts and pre-manufacturing notice tracking

CAS Chemical Compliance Index is backed by the same scientific rigour and curatorial expertise that underpins CAS REGISTRY®, relied upon by scientists, manufacturers, regulators, and data scientists worldwide. The platform is suitable for enterprises of all sizes operating in regulated industries such as agriculture, chemicals, and materials science, providing a dependable foundation for global compliance strategy.