NSF-Funded Test Bed Lets Researchers Program Automated Biomanufacturing Workflows

Aug 4, 2026
A bioreactor in a biomanufacturing lab, showcasing intricate details and lab equipment in the background.AI-generated from publicly available materials.

The University of Maryland has received a $17.3 million grant from the National Science Foundation (NSF) to establish a test bed aimed at automating biomanufacturing workflows, enhancing research capabilities in this critical field.

The initiative, led by the Collaborative for the Realization of Autonomous Biomanufacturing (CRAB) Lab, is part of a broader NSF investment in programmable laboratory nodes, totaling $400 million. This network is designed to foster AI-enabled laboratories that can innovate and demonstrate new scientific and engineering methodologies. William Bentley, a key figure in the project, emphasized the lab's role as a national resource, providing access to advanced automation and experimental data for researchers across various sectors.

A significant challenge in biomanufacturing is the slow traditional molecular measurement processes that hinder real-time data processing, which is essential for training AI models. The CRAB Lab plans to implement a new electronic measurement tool developed in collaboration with the National Institute of Standards and Technology (NIST) and the FDA. This tool will allow for rapid data collection, enabling the identification of key biological indicators that correlate with product quality and optimizing manufacturing processes.

The CRAB Lab will also support 30 biopharmaceutical companies through the Advanced Mammalian Biomanufacturing Innovation Center, facilitating a collaborative environment for tackling industry challenges. With plans for educational programs to cultivate a skilled workforce, the lab aims to significantly reduce the timeline for biomanufacturing innovations, potentially transforming the landscape of biotherapeutic development.