Ypso-Facto

Ypso-Facto is a French company that develops software tools and provides scientific and technical consulting services for the development, optimization, scale-up, and tech transfer of chemical and biochemical processes. The company focuses primarily on biopharmaceutical applications, including biologics (monoclonal antibodies, blood-related products, vaccines), peptides, oligonucleotides, and other molecules such as nutraceuticals, amino acids, organic acids, sugars, and mineral ions. Ypso-Facto's approach combines mechanistic simulation with hands-on scientific expertise, and the company works in collaborative partnerships with its customers rather than as a purely transactional vendor.

Ypso-Facto reports having delivered over 200 customer projects, co-published scientific articles with five of the largest biopharmaceutical companies, supported two CDMOs with its modeling approach, and developed custom software for two equipment suppliers.

Software Products

• Ionic — a desktop tool for the development of chromatographic processes, available in an enterprise edition to support collaborative work.
• Bioreactor — a desktop tool for the development of cell culture and fermentation processes, also available in enterprise edition.
• Basic Design — a desktop tool providing a simplified, complete process view, available in enterprise edition.
• Eval — a desktop tool for economic and environmental analysis of processes, available in enterprise edition.
• Web Buffer — an online tool for the preparation of buffer solutions.

Scientific and Technical Services

• Enabling processes that are failing to reach specific performance targets.
• Optimizing process performance metrics such as purity, yield, productivity, and buffer consumption.
• Accelerating process development, including integration into harmonized platform strategies.
• Securing scale-up and technology transfer activities.
• Providing training and support for the use of Ypso-Facto software tools.

Custom Software Development

• Ypso-Facto develops custom software tailored to specific customer needs, drawing on a multidisciplinary team that includes product owners with scientific backgrounds, front-end and back-end developers, and test engineers.
• An example of this capability is the Proxima software, developed in a joint application development partnership with Novasep, which covers process stages from R&D through to routine production analysis and supports scale-up by converting lab recipes into flow or equipment diagrams.

Notable Customers and Collaborations

• Novasep — co-developed the Proxima software as a joint application development partner; the tool is used for industrialization assessment and scale-up.
• Johnson Matthey — the separation technologies R&D team at Johnson Matthey Technology Centre has used Ypso-Ionic (formerly ChromWorks) for separation process development and business-critical problem solving, and has worked with Ypso-Facto to build custom modeling tools.
• Sanofi — uses Ypso-Ionic within the Calipso project for downstream processing; Sanofi estimates the tool saves approximately 10% of technician and executive time per week and standardizes activity visualization across teams.
• A collaboration involving peptide synthesis (SPPS) resulted in a reported 57% reduction in solvent use for resin washing, achieved by combining predictive simulation with experimental work.

Ypso-Facto serves biopharmaceutical manufacturers, CDMOs, and equipment suppliers seeking to apply mechanistic modeling and simulation to process development and scale-up challenges across upstream and downstream processing.