GenomSys

GenomSys is a Swiss health software company founded in 2016 that accelerates personal genomics and precision medicine by providing innovative digital-age applications for genomic data processing and analysis. The company serves genomic diagnostic laboratories, blood transfusion centers, sequencing instrument manufacturers, and other life sciences organizations seeking to modernize their genomic data workflows. GenomSys played a pioneering role in the development and publication of the ISO/IEC 23092 MPEG-G standard — the only ISO standard for genomic data — and builds its entire product portfolio on top of this open international standard.

Headquartered in Lugano, Switzerland, with a registered office at the EPFL Innovation Park in Lausanne and an MPEG-G Competence Center in Milan, GenomSys brings together a multicultural team of geneticists, bioinformaticians, mobile developers, and software engineers. The company is an ISO 13485-certified manufacturer of software for medical devices, reflecting its commitment to quality and Swiss precision across all its solutions.

GenomSys MPEG-G Toolkit

• Enables organizations to implement the ISO/IEC 23092 MPEG-G standard throughout their genomic data processing workflows.
• Provides rapid access and transmission, making genomic data available for processing within seconds instead of hours.
• Consolidates raw and aligned sequencing data, genome assemblies, annotations, and metadata into a single unified data container.
• Delivers up to 77% smaller file sizes while enabling faster data search and access in compressed domains.
• Includes built-in data protection with consistent traceability, precise access control, and role segregation.
• Supports a collaborative and open model, a highly scalable multi-infrastructure environment, and an unmatched connected mobile platform.

GenomSys Secondary Analysis Platform

• An ISO/IEC 23092 MPEG-G native, cloud-based germline pipeline built with standard technologies to conduct secondary analysis for any germline application.
• Supports automated compression and upload of genomic files, integrating closely with sequencing machines to produce smaller files and enable faster data transmission from the outset.
• Accelerates time-to-market for genomic applications by providing a secondary analysis layer that can be easily interfaced with tertiary analysis tools, allowing manufacturers to focus on their core competencies.
• Unleashes the full benefits of MPEG-G, including single unified syntax, rapid selective access, lossless compression, and built-in security.

Platform-Enabled Diagnostic Applications

• GenomSys Variant Analyzer: The only germline analysis software natively operating in MPEG-G, optionally connected directly with the MPEG-G Toolkit. Targeted at hereditary disease diagnostics through Whole Exome Sequencing. Benefits include faster data upload and processing via MPEG-G support, no onboarding or IT expertise required, and reliable annotation through access to Varsome's curated database.
• GenomSys Blood Typer: The first-of-its-kind software for the characterization of blood groups based on Next-Generation Sequencing (NGS) data, aligned with the latest developments from the International Society for Blood Transfusion. Designed for blood transfusion centers, it offers high-throughput analysis, a single comprehensive test covering 36 blood groups, and easy adaptability to novel scientific knowledge.

Core Technology and Standard: MPEG-G (ISO/IEC 23092)

• MPEG-G is described as the comprehensive ISO standard for genomic data — analogous to what MP3 is for audio — designed to enable interoperable, scalable, and efficient representation, storage, and distribution of large volumes of genomic data.
• GenomSys led and substantially contributed to the development and publication of this standard in 2020.
• The standard underpins all GenomSys products and ensures full interoperability and future-proofing of customer data and solutions.
• Built-in MPEG-G encryption ensures that sensitive genomic information is carefully protected and remains in the hands of the individual.

Mission and Strategic Focus

• GenomSys's mission is to accelerate personal genomics by providing an open standard platform to enable scalable and secure genomic 2.0 applications.
• The company aims to bring genomics into the digital age, supporting laboratories in coping with growing data volumes and the need for faster, reliable results.
• GenomSys is building a bridge between genomic experts and individuals, enabling convenient and comprehensive use of genomic analysis — including mobile-accessible DNA data — so that everyone can access and review their DNA whenever and wherever needed.
• The company supports the vision of personalized medicine, recognizing that genomic differences mean drugs and treatments act differently based on individual DNA.

Investors and Partners

• Romed SpA: A single-family office founded in 1985, investing across liquid asset classes and VC portfolios.
• Club degli Investitori: The most active business angel network in Italy, based in Turin, with more than 170 member investors and a portfolio of 25 companies.
• Elysia Capital: The single family office of the Buono-Lopera family, focused on sustainable innovation, education, well-being, and social impact.
• Diagnóstica Longwood: A partner offering products and technologies for in vitro diagnostics and research across immunology, transplant, genetics, hematology, oncology, and blood banking.
• HandsOnGen: A research, development, and consulting company combining operational excellence with cross-disciplinary innovation.

In 2024, GenomSys incorporated its Italian subsidiary GenomSys S.r.l. and established the MPEG-G Competence Center in Milan, where a dedicated team of computer engineers and bioinformaticians continues to advance the MPEG-G standard, develop cutting-edge software solutions, and provide technical support to clients worldwide.