Boltz

Boltz is an AI-driven computational drug discovery platform designed to help scientists accelerate the process of building better molecules. By combining frontier AI models with intelligent agents, Boltz empowers researchers across the drug discovery pipeline—from early hit identification through to lead optimization—enabling every scientist to reshape biology with the power of AI.

The Boltz Platform serves computational and medicinal chemists, structural biologists, and drug discovery teams seeking to dramatically reduce the time and resources required to identify and refine therapeutic candidates. Boltz offers both a cloud-based lab environment and open-source foundational models, making it accessible to academic researchers and biopharma organizations alike.

Boltz Lab Platform

• A unified platform for computational drug discovery that brings together frontier AI models and intelligent agents in a single environment
• Target Definition: Define and refine biological targets with AI assistance to establish a strong foundation for downstream discovery work
• Distributed Design: Run large-scale molecular screening across distributed infrastructure to explore chemical and protein space at scale
• Iterative Refinement: Integrate experimental data back into the platform to continuously improve model outputs and candidate quality

AI Agents

• Small Molecule Agent: AI-powered screening that explores vast chemical spaces in hours rather than months, dramatically compressing traditional timelines
• Protein Design Agent: Designs novel proteins with precision, validated across a wide variety of modalities and biological targets

Open Source Foundation

• Boltz's agents are powered by widely adopted open-source biomolecular modeling models that are freely available and battle-tested by the global research community
• The open-source models have accumulated over 3,000 GitHub stars, 4,000+ Slack community members, and more than 1 million downloads
• Boltz-1: A widely adopted open-source all-atom co-folding model, delivering results up to 1,000x faster than conventional approaches
• Boltz-2: Described as the world's best AI affinity prediction model, approaching the accuracy of Free Energy Perturbation (FEP) methods at 1,000x the speed
• BoltzGen: A universal binder design model capable of designing proteins to arbitrary targets, supporting broad applicability across discovery programs

Partnerships and Team

• Boltz partners with pioneering research and biopharma teams to tackle the most challenging problems in drug discovery
• The company is actively building a world-class team focused on pushing the boundaries of AI-driven drug discovery

Boltz combines an open-source research ethos with a powerful commercial platform, positioning itself as a comprehensive solution for teams looking to leverage cutting-edge AI across the full spectrum of computational drug discovery.