Aetion

Aetion, now a Datavant company, is a healthcare technology company that builds real-world evidence (RWE) software and analytics solutions for the life sciences industry. The company's mission is to turn real-world data into decision-grade evidence that shapes how medical innovations are understood, evaluated, and adopted. Aetion serves a broad range of stakeholders, including biopharma companies, payers, and regulatory agencies, with 17 of the top 20 global biopharma companies relying on its solutions.

At the core of Aetion's offering is the Aetion Evidence Platform®, a scalable, data-agnostic technology infrastructure that supports evidence generation across diverse data sources and formats. The platform incorporates validated analytical methods, data ingestion and preparation capabilities, and pre-built tools designed to accelerate and standardize the production of real-world evidence. Aetion's platform enables studies to be completed up to six times faster than traditional SAS-based approaches, compressing timelines from months to weeks.

Aetion Evidence Platform® — Core Software Modules

• Aetion® Discover: Enables users to visualize rapid, validated insights through real-world data, supporting exploratory analysis and evidence generation at speed.
• Aetion® Activate: Streamlines data preparation through guardrailed workflows, ensuring data is properly structured and ready for rigorous analysis.
• Aetion® Substantiate: Transforms real-world data into decision-grade evidence, supporting regulatory submissions, health technology assessments, and payer decisions.
• Aetion® Generate: Leverages AI-driven technology to safeguard patient privacy while ensuring the analytical utility of sensitive health data.

Aetion® Science & Research Services

• Expert-delivered real-world evidence services that complement the software platform with scientific and methodological depth.
• Helps organizations build smarter, more comprehensive evidence strategies tailored to their specific regulatory, market access, or clinical needs.
• Accelerates the generation of insights by combining Aetion's technology with hands-on scientific expertise.
• Designed to help clients answer complex research questions with confidence, including trial emulations, comparative effectiveness studies, and safety analyses.

Data & Partner Ecosystem

• Aetion maintains partnerships with more than 80 data providers, enabling evidence generation across a wide variety of real-world data sources and formats.
• The platform is data-agnostic, meaning it can ingest and work with claims data, electronic health records (EHR), and other administrative data types.
• Aetion has a formal partnership with the GetReal Institute, supporting studies and projects aimed at raising awareness among regulatory agencies, HTA bodies, and payers about the role of real-world evidence in healthcare decision-making.
• Aetion is now part of Datavant following a completed acquisition, further expanding its data connectivity and ecosystem reach.

Key Capabilities & Differentiators

• Validated analytical methods that ensure reproducibility and scientific rigor across studies.
• Pre-built analytical tools that reduce setup time and standardize evidence generation workflows.
• AI-driven privacy-preserving technology to balance data utility with patient confidentiality requirements.
• Trusted by leading global biopharma companies, regulators, and payers for critical healthcare decisions.
• Active research output published through the Aetion Evidence Hub, covering topics such as real-world persistence in HIV treatment, randomized controlled trial emulations, and information bias in EHR and claims data.

Aetion's combination of purpose-built software, scientific services, and an extensive data partner network positions it as a comprehensive partner for organizations seeking to generate, communicate, and act on real-world evidence across the full lifecycle of medical innovation.